A combination extract of ginseng, epimedium, polygala, and tuber curcumae increases synaptophysin expression in APPV717I transgenic mice

Table 1 Escape latencies of 7-month-old mice

Group	Day 3	Day 4	Day 5
Control	36.80 ± 12.60	32.87 ± 15.5	27.53 ± 14.21
APP	50.33 ± 9.39^▲▲	47.73 ± 8.65^▲▲	44.87 ± 11.98^▲▲
APP + D	38.25 ± 14.41^●	34.42 ± 12.84^●	30.58 ± 15.42^●
APP + Gl	40.93 ± 14.11	36.93 ± 13.78^●	35.00 ± 15.75
APP + Gm	42.92 ± 13.05	38.58 ± 14.15	31.42 ± 14.80^●
APP + Gh	38.45 ± 14.12^●	35.27 ± 14.01^●	30.91 ± 13.01^●

The effects of GEPT on escape latency in 7-month-old mice (n = 12) were assessed in orientation navigation tests using the Morris Water Maze (MWM). Data are expressed as mean ± standard deviation (SD). Control: C57BL/6 J mice; APP: APPV717I mice; APP + D: APP mice treated with donepezil; APP + Gl: APP mice treated with GEPT (low dose); APP + Gm: APP mice treated with GEPT (medium dose); APP + Gh: APP mice treated with GEPT (high dose). P < 0.05 vs. APP mice alone; ^▴▴P < 0.01 vs. control mice, one-way ANOVA.

ISSN: 1749-8546