Group | Average optical density |
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7-month-old mice | 11-month-old mice |
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Control | 0.020 ± 0.002 | 0.026 ± 0.009 |
APP | 0.013 ± 0.003▲▲ | 0.015 ± 0.004▲ |
APP + D | 0.017 ± 0.003 | 0.024 ± 0.008 |
APP + Gl | 0.016 ± 0.003 | 0.027 ± 0.006● |
APP + Gm | 0.017 ± 0.005 | 0.028 ± 0.007● |
APP + Gh | 0.019 ± 0.005 | 0.031 ± 0.011●● |
- The effects of GEPT extract on the expression of SYP in the hippocampal CA1 region in 7- and 11-month-old mice (n = 5 per group) were assessed by IHC staining. Average optical densities of the SYP positive neuronal area (anti-body for SYP, 1:400) are expressed as mean ± standard deviation (SD). Control: C57BL/6 J mice; APP: APPV717I mice; APP + D: APP mice treated with donepezil; APP + Gl: APP mice treated with GEPT (low dose); APP + Gm: APP mice treated with GEPT (medium dose); APP + Gh: APP mice treated with GEPT (high dose). P < 0.05 vs. APP mice alone, P < 0.01 vs. APP mice; ▴▴P < 0.01 vs. control mice, one-way ANOVA.