Table 1 Beneficial effects of SA-B and propranolol on MI biomarkers
From: Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B
Biomarkers | Sham group | MI group | SA-B group | Propranolol group | P value | |
|---|---|---|---|---|---|---|
|  | Mean ± SD a | Mean ± SD | Mean ± SD | Mean ± SD | SA-B vs . MI | Propranolol vs . MI |
Allantoin | 23.87 ± 4.14 | 0.00 ± 0.00 | 20.32 ± 5.36 | 23.16 ± 8.17 | 0.000 | 0.000 |
1-Phenylethylamine | 4.13 ± 1.88 | 23.66 ± 1.33 | 12.61 ± 0.96 | 9.42 ± 1.36 | 0.001 | 0.000 |
Hypoxanthine | 0.00 ± 0.00 | 14.72 ± 14.01 | 6.68 ± 2.86 | 0.00 ± 0.00 | 0.001 | 0.000 |
L-Valine | 37.98 ± 3.80 | 13.17 ± 2.14 | 22.75 ± 4.25 | 29.41 ± 6.31 | 0.002 | 0.001 |
L-Isoleucine | 122.84 ± 21.91 | 39.18 ± 2.37 | 92.59 ± 12.26 | 139.28 ± 26.48 | 0.001 | 0.000 |
Carnosine | 16.18 ± 2.70 | 0.00 ± 0.00 | 22.13 ± 04.27 | 19.35 ± 2.34 | 0.000 | 0.000 |
L-isoleucyl-L-Proline | 28.69 ± 3.90 | 79.23 ± 21.02 | 52.15 ± 14.06 | 41.32 ± 20.49 | 0.027 | 0.011 |
Phytosphingosine | 16.74 ± 1.89 | 82.93 ± 10.12 | 32.17 ± 6.29 | 41.38 ± 5.44 | 0.000 | 0.000 |
Dihydrosphingosine | 26.02 ± 0.99 | 146.98 ± 15.82 | 52.18 ± 11.40 | 31.37 ± 7.14 | 0.001 | 0.000 |
2',3'-Cyclic GMP | 6.30 ± 0.81 | 37.05 ± 5.97 | 15.16 ± 3.49 | 11.32 ± 2.40 | 0.001 | 0.000 |
2',3'-Cyclic AMP | 30.33 ± 1.78 | 190.63 ± 16.91 | 153.21 ± 19.48 | 51.43 ± 8.46 | 0.008 | 0.000 |
Dihydrobiopterin | 42.64 ± 4.78 | 8.23 ± 3.82 | 19.18 ± 8.31 | 39.27 ± 8.19 | 0.015 | 0.000 |
Xanthine | 0.00 ± 0.00 | 25.94 ± 6.39 | 24.13 ± 7.51 | 0.00 ± 0.00 | 0.805 | 0.000 |
Inosine | 0.00 ± 0.00 | 12.84 ± 3.49 | 12.03 ± 0.89 | 0.00 ± 0.00 | 0.913 | 0.000 |
Glyceraldehyde | 189.71 ± 13.83 | 31.23 ± 2.72 | 99.30 ± 9.47 | 159.29 ± 12.69 | 0.000 | 0.000 |
L-Phenylalanine | 14.65 ± 4.69 | 0.00 ± 0.00 | 5.34 ± 2.06 | 9.28 ± 2.44 | 0.000 | 0.000 |
L-Tryptophan | 64.74 ± 12.98 | 20.06 ± 1.15 | 77.27 ± 2.40 | 59.45 ± 5.46 | 0.000 | 0.000 |
2-oxoisocaproic acid | 27.85 ± 3.98 | 6.13 ± 1.23 | 17.33 ± 3.54 | 29.75 ± 4.94 | 0.000 | 0.000 |
5-Phosphoribosylamine | 87.81 ± 4.96 | 211.14 ± 15.24 | 203.47 ± 10.26 | 129.32 ± 24.94 | 0.871 | 0.002 |
15(S)-HETE | 0.00 ± 0.00 | 243.89 ± 99.98 | 71.67 ± 4.40 | 0.00 ± 0.00 | 0.001 | 0.000 |
Thromboxane B2 | 2.87 ± 1.95 | 18.27 ± 2.92 | 11.03 ± 0.64 | 9.42 ± 3.38 | 0.002 | 0.001 |