Time course changes of anti- and pro-apoptotic proteins in apigenin-induced genotoxicity

Chinese Medicine

Table 3 The effect of apigenin on cell cycle kinetics

Agents	Mean (± SD) number of cells in the 1^st, 2^nd, 3^rd, and subsequent mitotic divisions
	1^st	2^nd	3^rd+
Untreated control	4.3 ± 1.15	39.0 ± 9.54	89.7 ± 20.55
Vehicle control	5.0 ± 2.65	42.0 ± 10.44	103.0 ± 9.17
AP (1 μM)	4.0 ± 2.65	50.0 ± 9.54	97.3 ± 14.05
ΑP (10 μΜ)	7.4 ± 3.65	57.2 ± 16.57	85.2 ± 17.34
AP (20 μΜ)	20.2 ± 5.40*^,a,b	89.4 ± 20.38*^,c	34.2 ± 16.45*^,a,d

*P ≤ 0.01 vs. vehicle control; ^aP < 0.01 vs. 1 μM; ^bP < 0.05 vs. 10 μΜ; ^cP < 0.05 vs. 1 and 10 μΜ; ^dP < 0.01 vs. 10 μΜ.

ISSN: 1749-8546