Fig. 1

CKN attenuated the formation of atherosclerotic lesions in ApoE^−/− mice. The design of the experiments (A). Representative images of aortic lesions in the thoracic aorta (B) and quantification of atherosclerotic lesions shown as the percentage of thoracic aorta (C). Representative images of aortic lesions in the brachiocephalic trunk (D) and quantification of atherosclerotic lesions shown as a percentage of the brachiocephalic trunk (E). The serum lipid levels of total cholesterol (TC) (F), total triglyceride (TG) (G), low-density lipoprotein-cholesterol (LDL-C) (H) and high-density lipoprotein-cholesterol (HDL-C) (I). Serum and local levels of IL-1β (J) and TNF-α (K) were modulated by CKN. Data are presented as mean ± SD (n = 6) and analyzed by ANOVA with Dunnett’s post-hoc analysis. *P < 0.05, **P < 0.01; ***P < 0.001, ****P < 0.0001