Fig. 5

Predicted up and down-regulated DEG-related MTI network. A The annotation label “N” represents NFE2L2 pathway, “F” represents Ferroptosis, and “C” represents cellular iron ion homeostasis. B “O” represents organic hydroxy compound transport, “N” represents negative regulation of ERK1 and ERK2 cascade, and “C” represents cholesterol homeostasis. The rectangle denotes mRNA, the rhombus denotes miRNA (blue: down-regulated; pink: up-regulated). Dashed line: target prediction from 1 database. Grey line: target prediction from 2 databases. Rectangles with black rim: DEGs found in our highly enriched functions