Fig. 7

PNS regulates miR-139-5p and miR-24-3p to up-regulate ant-oxidation related proteins in INS-1 cells. A The binding sites of miR-139-5p and miR-24-3p on WT GCLc (red), and the mutant type GCLc (blue). B The relative luciferase activity with control or miR-139-5p mimics or miR-24-3p mimics overexpression in GCLc and SOD1 WT or MT groups *p < 0.05; **p < 0.01. C Representative immune blots D and quantification of GCLc, Hmox1, and SOD1 protein expression level with control or different PNS concentration treatment in INS-1 cells (L, 11.2 mg/mL; M, 20.2 mg/mL; and H, 29.1 mg/mL)