Fig. 2

Bioinformation and RNA-seq analysis in PTECs suggested that the treatment of HUA with GGQLD may be related to innate lymphoid cells and clock genes. A The figure of network pharmacology analysis revealed the potential pathway of GGQLD in the treatment of HUA. B The RNA-seq analysis in PTECs stimulated with high uric acid before and after intervention by GGQLD shows the different expression in ILC development related genes and clock genes. C The diagram shows the key genes and cytokines involved in the biological process of ILC development. D Protein–protein interaction and gene co-expression network about the genes related to ILC development and circadian rhythm which obtained from the RNA-seq results. E 10 hub genes were identified based on the protein–protein network in D constructed in the STRING database with Cytoscape software