Fig. 4

GGQLD may treat HUA by regulating clock genes in PBMCs. A Τhe bar plot shows the level of IL-18 and IL-1β in plasma from patients in NC, HUA before and after GGQLD treatment groups according to the results of ELISA. Regression coefficient matrix shows the relationship between cytokine (IL-18, IL-1β) and blood biochemical indexes. B Linear regression model shows the association between SUA levels and the proportion of ILCs, ILC3-ILC2 ratio in PBMCs. C Stratified by age and group (NC, HUA before and after GGQLD treatment), the heatmap shows the relative RNA expression of clock genes (NFIL3, REV-ERBα, CRY2, CLOCK, PER2 and HDAC3) in PBMCs. D Regression coefficient matrix shows the relationship between the level of biological clock genes and SUA levels. In all statistical plots, data are expressed as the mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001