Fig. 2

Inhibitory activity of glabridin, BAY11-7082, and Ro106-9920 on the activation of NF-κB in human platelets. Washed platelets were preincubated with 0.1% DMSO, glabridin (30 µM), BAY11-7082 (10 µM), or Ro106-9920 (10 µM), followed by the addition of collagen (1 µg/mL) to trigger NF-κB activation for the immunoblotting of A IKK, B IκBα, and C p65 phosphorylation as well as D IκBα degradation. Data are presented as mean ± standard error of the mean (n = 4). ***P < 0.001, compared with the resting control (Tyrode’s solution); ^###P < 0.001, compared with the 0.1% DMSO-treated group