Fig. 3

GQD improves Meth-altered mice colon metabolism in vivo. A PCA among groups. B PCoA among groups. C The Venn (upper) and column (lower) diagrams of different metabolites in colon among indicated groups. D The ROC curves and AUC of the screened-out differential metabolites of MV vs SV and MG vs MV. E Volcano graph of changed gut bacteria in MV vs SV and MG vs MV. F The top 10–20 enriched KEGG pathways of different metabolites in colon between SV and MV groups as well as MV and MG groups. G The comparison of changed Akkermansia metabolism in groups of MV vs SV and MG vs MV. SV, vehicle treatment in saline withdrawal mice. MV, vehicle treatment in Meth-withdrawn mice. SG, GQD treatment in saline withdrawal mice. MG, GQD treatment in Meth-withdrawn mice