Gegen-Qinlian decoction alleviates anxiety-like behaviors in methamphetamine-withdrawn mice by regulating Akkermansia and metabolism in the colon

Table 1 Common enriched KEGG pathways of gut metabolites in groups of MV vs SV and MG vs MV

	KEGG	MV vs SV	MG vs MV
Pos	Bile secretion	Hydrocortisone, Lithocholic acid; Prostaglandin F2α	Hydrocortisone
	Neuroactive ligand-receptor interaction	Hydrocortisone, Prostaglandin F2α	Hydrocortisone
	Aldosterone-regulated sodium reabsorption	Hydrocortisone	Hydrocortisone
	Prostate cancer	Hydrocortisone	Hydrocortisone
	Cortisol synthesis and secretion	Hydrocortisone	Hydrocortisone
	Cushing's syndrome	Hydrocortisone	Hydrocortisone
	Pathways in cancer	Hydrocortisone	Hydrocortisone
	Vitamin digestion and absorption	Riboflavin	Thiamine
	Steroid hormone biosynthesis	Hydrocortisone	Hydrocortisone
Neg	beta-Alanine metabolism	l-Histidine	Uracil
	Protein digestion and absorption	l-Histidine	l-Asparagine
	Tyrosine metabolism	Hydroquinone	Hydroquinone
	Central carbon metabolism in cancer	l-Histidine	l-Asparagine
	Aminoacyl-tRNA biosynthesis	l-Histidine	l-Asparagine
	Alanine, aspartate and glutamate metabolism	Citric acid	l-Asparagine

ISSN: 1749-8546