A systematic review of the research progress of traditional Chinese medicine against pulmonary fibrosis: from a pharmacological perspective

Table 5 Details about some traditional Chinese medicines improving pulmonary fibrosis by inhibiting endoplasmic reticulum stress

No	Source	Genus information	Traditional efficacy	Active compound	Experiment model	Administration dose	Therapeutic target	cytokine	Refs.
1	Citri reticulatae pericarpium	Rutaceae	Regulating qi and eliminating food, resolving phlegm and relieving cough	citrus alkaline extracts (CAEs)	BLM-induced PF mice and A549 cells	Mice (32, 64, 96 mg/kg)	Regulates PERK and ATF3/PINK1 signaling	PERK, ATF3, PINK1	[336]
1	Citri reticulatae pericarpium	Rutaceae		citrus alkaline extracts (CAEs)	BLM-induced PF mice and A549 cells	cell (50, 100, 200 μg/mL)	Regulates PERK and ATF3/PINK1 signaling	PERK, ATF3, PINK1	[336]
2	Hippophae fructus	Elaeagnaceae	Invigorate the stomach and eliminate food, relieve cough and expectoration	Isorhamnetin	BLM-induced PF mice	Mice (10, 30 mg/kg)	Suppress EMT	PERK, α-SMA, Col III, CHOP, GRP78, TGF-β1	[194]
2	Hippophae fructus	Elaeagnaceae		Isorhamnetin	BLM-induced PF mice	Cell (25, 50, 100 μmol/L)	Suppress EMT	PERK, α-SMA, Col III, CHOP, GRP78, TGF-β1	[194]
3	Lonicerae japonicae flos	Caprifoliaceae	Clearing heat and detoxification, dispelling wind and detoxification	Chlorogenic acid	BLM-induced PF mice	Mice (15, 30, 60 mg/kg)	Inhibits endoplasmic reticulum stress	α-SMA, Col I, CHOP, PERK, IRE-1, GRP78	[356]

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