Fig. 3

EmB-MO restored the integrity of colon tissue in mice with DSS-induced ulcerative colitis. A Representative images of hematoxylin and eosin (H&E)-stained colon tissues. Scale bar = 100 µm. B Histological scores of colon tissues in each group. Data represent the mean ± standard error of the mean (n = 3). ^***P < 0.001 vs. control group, ^#P < 0.05, ^###P < 0.001 vs. ulcerative colitis group. 5-ASA: 5-aminosalicylic acid, 100 mg/kg/d; Em: Emodin, 8 mg/kg/d; EmB-L: Emodin-borate nanoparticles, 3 mg/kg/d; EmB-H: 6 mg/kg/d; EmB-MO-L: EmB modified with oligomeric mannitol into microgels, 3 mg/kg/d; and EmB-MO-H: 6 mg/kg/d