Fig.14

The results of MDS. 3D figures of free energy landscape of A MMP13-Salvianolic acid and B MMP13-(E,E)-3,5-Di-O-caffeoylquinic acid. C RMSD of backbone atoms of docked complex of Salvianolic acid (blue) and docked complex of (E,E)-3,5-Di-O-caffeoylquinic acid (red). D RMSF of the complex of Salvianolic acid (blue) and (E,E)-3,5-Di-O-caffeoylquinic acid (red). E Rg of complex of Salvianolic acid (blue) and (E,E)-3,5-Di-O-caffeoylquinic acid (red). F SASA of the complex of Salvianolic acid (blue) and (E,E)-3,5-Di-O-caffeoylquinic acid (red). G Hydrogen bonds interaction of the complex of Salvianolic acid (blue) and (E,E)-3,5-Di-O-caffeoylquinic acid (red). The conformational changes of the complexes of MMP13-Salvianolic acid H and MMP13-(E,E)-3,5-Di-O-caffeoylquinic acid I at 25 ns intervals in MDS