Fig. 2

Effects of BJIKT on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) symptoms in AD mice fed a low AhR ligand diet. A Timeline for AD mice fed a low AhR ligand diet and treatment with BJIKT; B Final body weight was scored 10 weeks after AD induction; C Evaluation of the total dorsal skin and epithelial thickness by histological analysis; measurement of the levels of D neutrophils and (E) eosinophils by CBC analysis; F IgE plasma levels; G spleen weight; and the levels of H interferon-gamma (IFN)-γ and I interleukin (IL)-4 in splenocytes. Number of experiments conducted for group comparisons: Cont, n = 6; ^LowAhR, n = 6; ^LowAhR + AD, n = 7; and ^LowAhR + AD + BJ, n = 6. The values are expressed as the means ± standard error of the mean (SEM). *p < 0.05, **p < 0.01, ***p < 0.001 according to a one-way ANOVA followed by Tukey’s multiple comparisons