Fig. 4

Upregulation of AhR target genes by BJIKT in AD mice fed a low AhR ligand diet. RNA-seq analysis of the relative expression of AhR target genes (A) Ahr, (B) Ahrr, (C) CYP1A1, and (D) CYP1B1 in the skin. (E) A representative heatmap of the differentially expressed Cytochrome P450 family genes in the skin. F TheeExtracted ion chromatograms (EIC) of indole-3-carboxaldehyde as an AhR ligand in BJIKT-treated cells. Number of experiments conducted for group comparisons: Cont, n = 4; ^LowAhR, n = 4; ^LowAhR + AD, n = 4; and ^LowAhR + AD + BJ, n = 4. The values are expressed as mean ± SEM. *p < 0.05, **p < 0.01, according to a one-way ANOVA followed by Tukey’s multiple comparisons