From: Multi-target regulatory mechanism of Yang Xin Tang − a traditional Chinese medicine against dementia
Promoter | % Luciferase activity changes a,b | |||||
---|---|---|---|---|---|---|
PA | PS | RA | RC | RP | ||
Neurogenesis | ||||||
AP-1-RE | Aq | 15.4 ± 0.4c | 5.6 ± 1.0 | − 1.0 ± 1.3 | 1.0 ± 0.4 | − 6.2 ± 1.7 |
EtOH | − 6.4 ± 0.5 | − 10.7 ± 0.4 | 34.2 ± 5.6c | − 11.9 ± 1.8 | 36.8 ± 0.2c | |
CRE | Aq | − 3.5 ± 2.0 | − 4.3 ± 1.9 | − 6.5 ± 2.5 | − 9.8 ± 1.1 | − 0.9 ± 3.0 |
EtOH | 20.9 ± 1.8c | 0.8 ± 0.7 | 17.2 ± 2.8c | 9.0 ± 2.3 | 34.8 ± 0.3c | |
STAT3-RE | Aq | 4.7 ± 5.2 | − 12.2 ± 1.8 | 0.5 ± 1.8 | − 6.1 ± 3.9 | − 16.4 ± 3.2d |
EtOH | − 2.2 ± 1.7 | − 11.3 ± 1.1 | 12.7 ± 1.2 | 5.9 ± 2.7 | 0.6 ± 1.6 | |
Neuronal cell survival | ||||||
LILRE | Aq | 11.1 ± 0.5 | 4.8 ± 3.7 | 10.2 ± 1.0 | 7.8 ± 2.5 | 3.3 ± 0.2 |
EtOH | − 23.6 ± 0.6d | 13.9 ± 3.4 | 2.0 ± 0.7 | 13.3 ± 2.7 | 0.4 ± 0.5 | |
p53-RE | Aq | 7.7 ± 0.4 | − 5.4 ± 3.0 | 2.3 ± 0.9 | 7.1 ± 0.9 | 1.9 ± 2.4 |
EtOH | − 55.5 ± 0.9d | − 31.1 ± 0.4d | − 11.3 ± 2.1 | − 24.0 ± 1.3d | − 41.7 ± 1.8d | |
TARE | Aq | − 21.7 ± 1.3 | − 24.0 ± 3.8 | − 3.2 ± 0.7 | − 7.5 ± 0.4 | − 2.3 ± 1.0 |
EtOH | − 14.1 ± 3.2 | − 3.8 ± 6.8 | − 25.3 ± 0.2d | − 8.4 ± 2.3 | − 36.5 ± 1.7d | |
Aβ and NFT formation | ||||||
ISRE | Aq | 19.7 ± 5.1 | 43.3 ± 16.6c | 34.9 ± 11.7c | 8.6 ± 4.6 | 69.4 ± 1.0c |
EtOH | 2.9 ± 1.6 | − 16.0 ± 3.3d | − 5.0 ± 9.8 | 4.2 ± 2.1 | 30.3 ± 2.6c | |
GAS | Aq | − 3.6 ± 0.5 | 8.2 ± 6.5 | 0.3 ± 2.2 | − 3.3 ± 3.8 | 14.4 ± 12.1 |
EtOH | − 16.9 ± 1.0d | − 23.2 ± 1.7d | 2.5 ± 4.9 | − 18.4 ± 2.0d | − 3.6 ± 1.1 | |
NFκB-RE | Aq | − 13.8 ± 1.2d | − 17.7 ± 1.2d | − 4.2 ± 2.3 | − 8.3 ± 2.4 | − 14.3 ± 1.5d |
EtOH | − 22.7 ± 1.4d | − 6.6 ± 3.5 | 21.6 ± 3.6c | − 7.6 ± 5.0 | − 16.5 ± 0.9d |