Fig. 8
Network-based rational screening of chemical ingredient combinations for insomnia. The inferred mechanism-of-action networks for pairwise active ingredient combinations: (A) GABA plus coumestrol, (B) GABA plus stearic acid, and (C) stearic acid plus coumestrol. ZCA and ZCB indicate the network proximity (Z-score) between insomnia-associated proteins and ingredient A targets or ingredient B targets, respectively. SAB indicates the separation score of targets between ingredient A and ingredient B