Table 2 The main pharmacokinetic parameters of seven lignan components after SCE gavage in rats (x ± s, n = 6)
Parameters | Schisandrin | Schisandrol B | Deoxyschizandrin | Schizandrin B | Schizandrin C | Schisanhenol | Schisantherin A |
|---|---|---|---|---|---|---|---|
T1/2(h) | 1.68 ± 0.26 | 3.30 ± 0.55 | 4.19 ± 0.50 | 4.49 ± 0.02 | 7.15 ± 4.48 | 6.84 ± 2.62 | 5.18 ± 3.24 |
Tmax(h) | 2.00 ± 0.00 | 2.00 ± 0.00 | 2.67±1.16 | 2.00 ± 0.00 | 2.00 ± 0.00 | 4.00 ± 0.00 | 2.67 ± 1.16 |
Cmax(ng/ml) | 1078.54 ± 179.30 | 182.43 ± 19.98 | 136.74 ± 45.83 | 183.43 ± 66.96 | 24.65 ± 9.03 | 85.31 ± 8.10 | 75.81 ± 34.20 |
MRT0-∞(h) | 4.54 ± 0.70 | 5.75 ± 0.46 | 6.23 ± 0.77 | 9.03 ± 0.34 | 9.94 ± 4.56 | 11.09 ± 2.83 | 8.24 ± 1.24 |
CL(L/h/kg) | 4.62 ± 1.22 | 7.43 ± 2.02 | 9.68 ± 3.25 | 5.41 ± 1.47 | 10.17 ± 3.73 | 1.35 ± 0.18 | 1.25 ± 0.26 |
V(L/kg) | 11.14 ± 3.19 | 1419.21 ± 412.19 | 59.85 ± 25.71 | 35.04 ± 9.69 | 90.87 ± 28.97 | 12.93 ± 3.67 | 8.71 ± 3.71 |
AUC0-t(ng.h/ml) | 5774.32 ± 1456.47 | 1419.21 ± 412.19 | 946.23 ± 379.15 | 1615.77 ± 439.42 | 195.09 ± 87.05 | 1115.96 ± 160.10 | 672.45 ± 139.56 |
AUC0-∞(ng.h/ml) | 5775.05 ± 1457.02 | 1431.21 ± 410.25 | 960.14 ± 380.61 | 1627.57 ± 440.60 | 224.67 ± 129.91 | 1160.33 ± 205.58 | 709.09 ± 189.60 |