Fig. 3

Time-efficacy relationship and concentration-efficacy relationship of Acu-exo. A Experimental procedures. B Effects of exosomes (0.4 mg/mL) extracted from the circulating serum of normal mice treated with EA0, EA1, EA7, EA14, EA21 on the survival rate of sepsis mice. Acu-exo (0.1 mL/10 g, i.p.) should be administered 0.5 h before the LPS injection. C Effects of different concentrations (2 mg/mL, 0.8 mg/mL, 0.4 mg/mL, 0.2 mg/mL, 0.08 mg/mL) of exosomes extracted from the circulating serum of normal mice treated with EA7 on the survival rate of sepsis mice. Acu-exo (0.1 mL/10 g, i.p.) should be administered 0.5 h before the LPS injection. D Effect of different injection times of exosomes (EA7, 0.4 mg/mL) on the survival rate of sepsis mice. Acu-exo (0.1 mL/10 g, i.p.) should be administered either 0.5 h before or after the LPS injection. LPS, 12 mg/kg, i.p., n = 12/group. All data represent the mean ± SEM. *P < 0.05, compared to the sepsis group