Fig. 2

Effect of HGWD treatment on intestinal barrier, serum LPS, and DRG, serum, colon inflammation in OIPN mice. A The expression level of HMGB1, IL-6, and TNF-α in the DRG of OIPN mice treated with HGWD (magnification: 500×). B Relative levels of HMGB1, IL-6, TNF-α, and LPS in the serum of OIPN mice after HGWD treatment. C The expression level of HMGB1, IL-6, TNF-α, and ZO-1 in the colon of OIPN mice treated with HGWD (magnification: 200×). Data are expressed as mean ± SEM. #P < 0.05, ##P < 0.01 (compared with Vehicle group); *P < 0.05, **P < 0.01 (compared with OIPN group)