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Fig. 6 | Chinese Medicine

Fig. 6

From: Involvement of the Sch9/Rim15/Msn2 signaling pathway in the anti-aging activity of dendrobine from Dendrobium nobile Lindl. via modification of oxidative stress and autophagy

Fig. 6

Sch9/Rim15/Msn2 signaling pathway mediates the anti-aging effect of dendrobine. A The western blot result of phosphorylation level of sfGFP-Sch9-5HA after treatment with RA or dendrobine for 40 min. B The digital result of A. C, E Nuclear translocation of Rim15-GFP (C) and Msn2-GFP (E) upon dendrobine treatment. D, F Statistical results of C and E. Nine images of each group in C and five images of each group in E were selected randomly, calculated the percentage of cells with the overlap of green and blue fluorescence indicating the nuclear translocation of Rim15-GFP or Msn2-GFP. G Failure of dendrobine to extend the replicative lifespan of Δrim15 yeast mutant with K6001 background. The experiment was repeated three times and data from each experiment are displayed as mean ± SEM. *, **, *** represent significant difference compared with negative control (p < 0.05, p < 0.01, p < 0.001)

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Chinese Medicine

ISSN: 1749-8546

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