Fig. 2

Effects of LBP pretreated EVs on stroke outcome are dose-dependent . A In vivo experiment illustration. B In vivo imaging of DIR-labeled EV. C Changes in body weight of mice in each group throughout the experiment. D Representative images of TTC stained coronal brain sections and E quantitative analysis of infarct volume of PBS-treated, NSC-EV treated, and L-NSC-EV treated and H-NSC-EV treated rats 72 h after ischemia. F and G The long-term effect of NSC-EV pretreated with or without LBP on sensorimotor function was assessed by modified mNSS score F and grip test G 3, 7, 14, and 28 days after MCAO. H Representative images and I quantification of CBF before, post, and up to 4 weeks after stroke. n = 6 animals per group. Data are shown as mean ± SD. Data are statistically different from each other with *P < 0.05, **P < 0.01, and ***P < 0.001