Fig. 4

LBP pretreated NSC-EVs suppressed inflammatory response and reduced neuronal apoptosis after stroke . OGD-exposed neurons were incubated with PBS, NSC-EV, L-NSC-EV, and H-NSC-EV. Cells incubated under standard cell culture conditions were used as negative control. A–C The mRNA expression of TNFα, IL-6, and IL-1β in the sham and ipsilateral side of the infarcted brain was measured by RT-qPCR at post stroke day 3 D Representative images and E quantification of TUNEL⁺ cells in the infarct border. Data are shown as mean ± SD. Data are statistically different from each other with *P < 0.05, **P < 0.01, and ***P < 0.001