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Fig. 2 | Chinese Medicine

Fig. 2

From: Xinyang tablet ameliorates sepsis-induced myocardial dysfunction by regulating Beclin-1 to mediate macrophage autophagy and M2 polarization through LncSICRNT1 targeting E3 ubiquitin ligase TRAF6

Fig. 2

XYT alleviated myocardial inflammation and improved cardiac function in SIMD mice by regulating LncSICRNT1 and TRAF6. SIMD mice were treated with low (194 mg/kg), medium (387 mg/kg) and high (774 mg/kg) doses of XYT for 7 continuous days. A Mouse body weight assessment, N = 12; B Cardiac function evaluated by echocardiography, N = 12; C LncSICRNT1 expression measured by RT-qPCR, N = 6; D TRAF6 protein level measured by Western blot, N = 6; and the most representative protein imprints were shown in the figure; E Changes in mouse myocardial tissues assessed by HE staining, N = 6; and the most representative tissue staining was represented in the figure F Levels of pro-inflammatory cytokines TNF-α, 1L-6, IL-1β and anti-inflammatory factors IL-10 and IL-4 measured by ELISA, N = 6. Data were expressed as mean ± SD. One-way ANOVA was applied for comparisons among multiple groups, followed by the Tukey's test. *p < 0.05, **p < 0.01

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Chinese Medicine

ISSN: 1749-8546

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