Fig. 2

CSO improved histopathological deteriorations in the joint and synovium of CIA rats. A H&E staining and Safranin O fast green staining of ankle joints. Blue arrows indicate inflammatory infiltration. Yellow arrows indicate cartilage erosion. B H&E staining of synovial tissues. Black arrows indicate vessel-like structures. C H&E score of joint. D Safranin O score of joint. E The number of vessel-like structures in synovial tissues. Datasets are shown as the mean ± SD. *P < 0.05, **P < 0.01 vs. CON group; ^#P < 0.05, ^##P < 0.01 vs. CIA group, n = 6