Fig. 9
From: Cyasterone ameliorates sepsis-related acute lung injury via AKT (Ser473)/GSK3β (Ser9)/Nrf2 pathway
Schematic representation of the protective effect of cyasterone on CLP-induced ALI via AKT (Ser473)/GSK3β (Ser9)/Nrf2 axis. Cyasterone pretreatment activates AKT and GSK3β, promotes Nrf2 nucleation, increases the expression of antioxidant enzymes such as NQO-1 and HO-1, thereby reducing ROS content, inhibiting NLRP3 inflammasome activation in macrophages, and exerts a mitigating effect on CLP-induced ALI