Fig. 7

ZCHP restrained the activation of pro-inflammatory cytokines, NF-κB, and M1 macrophage polarization biomarkers. A The mRNA levels of TNF-α and IL-1β (n = 4 per group); B Representative Western blot images and relative protein levels of p-NF-κB, NF-κB, TNF-α, and IL-1β in ApoE^−/− mice (n = 4 per group); C Representative image of immunohistochemical staining shows the expression of CD86 in the aortic arch and quantitative analysis (n = 3 per group, scale bars: 400 µm). * P < 0.05 and ** P < 0.01 vs. model; ^# P < 0.05 and ^## P < 0.01 vs. control