Table 4 Post-treatment triglycerides levels (mmol/L) in randomized controlled trials
Interventions | No. of trials [references] | No. of participants | Weighted mean difference (95% confidence interval) | P value |
|---|---|---|---|---|
RYR vs. no intervention/placebo | Â | Â | Â | Â |
Zhibituo vs. no intervention | 2 [22, 23] | 112 | -0.54 (-0.77 to -0.32) | < 0.00001 |
RYR supplement vs. placebo | 1 [7] | 83 | -0.25 (-0.47 to -0.03) | 0.03 |
Xuezhikang vs. placebo | 4 [8, 24–26] | 323 | -0.40 (-0.70 to -0.10)* | 0.008 |
Zhibituo vs. placebo | 3 [27–29] | 291 | -0.55 (-0.99 to -0.10) | 0.02 |
RYR vs. statins | Â | Â | Â | Â |
Xuezhikang vs. simvastatin | 14 [6, 30–42] | 1251 | -0.08 (-0.25 to 0.10)* | 0.39 |
Xuezhikang vs. pravastatin | 7 [44–50] | 592 | 0.04 (- 0.29 to 0.38)* | 0.79 |
Xuezhikang vs. lovastatin | 3 [51–53] | 168 | -0.07 (-0.16 to 0.01) | 0.09 |
Xuezhikang vs. atorvastatin | 1 [54] | 60 | -0.02 (-0.16 to 0.12) | 0.78 |
Xuezhikang vs. fluvastatin | 1 [55] | 118 | 0.09 (-0.1 4 to 0.32) | 0.44 |
Zhibituo vs. simvastatin | 9 [32, 56–63] | 732 | 0.05 (-0.17 to 0.26)* | 0.67 |
Zhibituo vs. provastatin | 1 [22] | 62 | -0.02 (-0.19 to 0.15) | 0.81 |
Zhibituo vs. lovastatin | 1 [57] | 45 | -0.21 (- 0.61 to 0.19) | 0.30 |
RYR vs. non-statin drugs | Â | Â | Â | Â |
Xuezhikang vs. inositol nicotinate | 7 [65–71] | 636 | -0.06 (-0.20 to 0.08) | 0.38 |
Xuezhikang vs. fenofibrate | 5 [32, 73–76] | 337 | 0.42 (-0.17 to 1.01)* | 0.16 |
Xuezhikang vs. gemfibrozil | 3 [77–79] | 160 | 0.41 (0.30 to 0.51) | < 0.00001 |
Xuezhikang vs. fish oils | 2 [80, 81] | 112 | -0.71 (-0.97 to -0.44) | < 0.00001 |
Xuezhikang vs. alginic sodium diester | 1 [84] | 60 | 0.04 (-0.21 to 0.29) | 0.75 |
Xuezhikang vs.conjugated estrogens | 1 [85] | 44 | -0.82 (-1.31 to -0.33) | 0.001 |
Xuezhikang vs. elastase | 1 [86] | 107 | 0.00 (-0.31 to 0.31) | 1.00 |
Xuezhikang vs. biphenalbid | 1 [87] | 64 | -0.43 (-0.8 1 to -0.05) | 0.03 |
Zhibituo vs. inositol nicotinate | 7 [88–93, 95] | 598 | -0.39 (-0.62 to -0.16)* | 0.0008 |
Zhibituo vs. fish oils | 5 [97–100, 102] | 394 | -0.12 (-0.29 to 0.05) | 0.17 |
Zhibituo vs. fenofibrate | 2 [32, 104] | 248 | 0.33 (-0.12 to 0.78) | 0.15 |
RYR vs. RTR | Â | Â | Â | Â |
Xuezhikang vs. Zhibituo | 7 [32, 106–111] | 727 | 0.05 (-0.17 to 0.27)* | 0.66 |