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Table 4 Post-treatment triglycerides levels (mmol/L) in randomized controlled trials

From: Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials

Interventions No. of trials [references] No. of participants Weighted mean difference (95% confidence interval) P value
RYR vs. no intervention/placebo     
Zhibituo vs. no intervention 2 [22, 23] 112 -0.54 (-0.77 to -0.32) < 0.00001
RYR supplement vs. placebo 1 [7] 83 -0.25 (-0.47 to -0.03) 0.03
Xuezhikang vs. placebo 4 [8, 24–26] 323 -0.40 (-0.70 to -0.10)* 0.008
Zhibituo vs. placebo 3 [27–29] 291 -0.55 (-0.99 to -0.10) 0.02
RYR vs. statins     
Xuezhikang vs. simvastatin 14 [6, 30–42] 1251 -0.08 (-0.25 to 0.10)* 0.39
Xuezhikang vs. pravastatin 7 [44–50] 592 0.04 (- 0.29 to 0.38)* 0.79
Xuezhikang vs. lovastatin 3 [51–53] 168 -0.07 (-0.16 to 0.01) 0.09
Xuezhikang vs. atorvastatin 1 [54] 60 -0.02 (-0.16 to 0.12) 0.78
Xuezhikang vs. fluvastatin 1 [55] 118 0.09 (-0.1 4 to 0.32) 0.44
Zhibituo vs. simvastatin 9 [32, 56–63] 732 0.05 (-0.17 to 0.26)* 0.67
Zhibituo vs. provastatin 1 [22] 62 -0.02 (-0.19 to 0.15) 0.81
Zhibituo vs. lovastatin 1 [57] 45 -0.21 (- 0.61 to 0.19) 0.30
RYR vs. non-statin drugs     
Xuezhikang vs. inositol nicotinate 7 [65–71] 636 -0.06 (-0.20 to 0.08) 0.38
Xuezhikang vs. fenofibrate 5 [32, 73–76] 337 0.42 (-0.17 to 1.01)* 0.16
Xuezhikang vs. gemfibrozil 3 [77–79] 160 0.41 (0.30 to 0.51) < 0.00001
Xuezhikang vs. fish oils 2 [80, 81] 112 -0.71 (-0.97 to -0.44) < 0.00001
Xuezhikang vs. alginic sodium diester 1 [84] 60 0.04 (-0.21 to 0.29) 0.75
Xuezhikang vs.conjugated estrogens 1 [85] 44 -0.82 (-1.31 to -0.33) 0.001
Xuezhikang vs. elastase 1 [86] 107 0.00 (-0.31 to 0.31) 1.00
Xuezhikang vs. biphenalbid 1 [87] 64 -0.43 (-0.8 1 to -0.05) 0.03
Zhibituo vs. inositol nicotinate 7 [88–93, 95] 598 -0.39 (-0.62 to -0.16)* 0.0008
Zhibituo vs. fish oils 5 [97–100, 102] 394 -0.12 (-0.29 to 0.05) 0.17
Zhibituo vs. fenofibrate 2 [32, 104] 248 0.33 (-0.12 to 0.78) 0.15
RYR vs. RTR     
Xuezhikang vs. Zhibituo 7 [32, 106–111] 727 0.05 (-0.17 to 0.27)* 0.66
  1. * Random effects model