Articles

Hierarchical chromatin features reveal the toxin production in Bungarus multicinctus

Bungarus multicinctus, from which a classical Chinese medicine is produced, is known as the most venomous land snake in the world, but the chromatin organization and transcription factor activity during venom rep...

Authors: Xuejiao Liao, Shuai Guo, Xianmei Yin, Baosheng Liao, Mingqian Li, He Su, Qiushi Li, Jin Pei, Jihai Gao, Juan Lei, Xiwen Li, Zhihai Huang, Jiang Xu and Shilin Chen

Towards a better understanding of Fagopyrum dibotrys: a systematic review

Fagopyrum dibotrys (F. dibotrys) (D.Don) H.Hara is a well-known edible herbal medicine in Asian countries. It has been widely used for the treatment of lung diseases, swelling, etc., and is also an important par...

Authors: Le-Le Zhang, Yan He, Feiya Sheng, Ying-Fan Hu, Yu Song, Wei Li, Jiarong Chen, Jinming Zhang and Liang Zou

Potential mechanism of Ziyin Tongluo Formula in the treatment of postmenopausal osteoporosis: based on network pharmacology and ovariectomized rat model

Amending from ancient classic, Ziyin Tongluo Formula (ZYTLF) has been prescribed to treat postmenopausal osteoporosis (PMOP) for decades with good curative effect. However, the possible mechanisms of it are st...

Authors: Rong-Bin Chen, Ying-Dong Yang, Kai Sun, Shan Liu, Wei Guo, Jin-Xin Zhang and Yong Li

Microwave technology: a novel approach to the transformation of natural metabolites

Microwave technology is used throughout the world to generate heat using energy from the microwave range of the electromagnetic spectrum. It is characterized by uniform energy transfer, low energy consumption,...

Authors: Qi Hu, Yanan He, Fang Wang, Jing Wu, Zhimin Ci, Lumeng Chen, Runchun Xu, Ming Yang, Junzhi Lin, Li Han and Dingkun Zhang

The emerging possibility of the use of geniposide in the treatment of cerebral diseases: a review

With the advanced discoveries in the field of pathogenesis, a series of cerebral diseases, such as cerebral ischaemia, Alzheimer's disease, and depression, have been found to have multiple signalling targets i...

Authors: Wenwen Zhang, Fangling Zhang, Qichao Hu, Xiaolin Xiao, Linbo Ou, Yuan Chen, Shiqing Luo, Yonghong Cheng, Yinxiao Jiang, Xiao Ma and Yanling Zhao

A novel multidimensional strategy to evaluate Belamcanda chinensis (L) DC and Iris tectorum Maxim based on plant metabolomics, digital reference standard analyzer and biological activities evaluation

Belamcanda chinensis (L.) DC. (BC) belongs to the family of Iridaceae and is widely cultivated and used in many Chinese patent medicine and Chinese medicinal formulae. However, due to the high similarities in app...

Authors: Hongxu Zhou, Yi Zhang, Hui Liang, Huijie Song, Jiaming Zhao, Li Liu, Jun Zeng, Lei Sun, Shuangcheng Ma and Dali Meng

Utilization of traditional Chinese medicine in the intensive care unit

Previous studies showed that traditional Chinese medicine (TCM) may be effective for patients with critical conditions. However, the extent to which TCM is used in intensive care units (ICUs) remains less inve...

Authors: Xia Zhang, Mingqi Wang, Wen Wang, Ling Li and Xin Sun

A comprehensive review of the botany, ethnopharmacology, biochemistry, pharmacology, pharmacokinetics and toxicity of Filifolium sibiricum (L.)Kitam

Filifolium sibiricum (L.)Kitam (F. sibiricum), a compositae plant, is especially used to inhibit drug-resistant bacteria in folk medicine. Modern pharmacological studies also confirmed a variety of pharmacologica...

Authors: Shaowa Lv, Qian Qiu, Qiuhong Wang and Haixue Kuang

Alpinia oxyphylla Miq extract reduces cerebral infarction by downregulating JNK-mediated TLR4/T3JAM- and ASK1-related inflammatory signaling in the acute phase of transient focal cerebral ischemia in rats

Post-ischemic inflammation is a crucial component in stroke pathology in the early phase of cerebral ischemia–reperfusion (I/R) injury. Inflammation caused by microglia, astrocytes, and necrotic cells, produce...

Authors: Chin-Yi Cheng, Su-yin Chiang, Shung-Te Kao and Shang-Chih Huang

The internationalization of TCM towards Portuguese-speaking countries

With the increasing demand for traditional Chinese medicine (TCM) in Portuguese-speaking countries (PSC), local regulatory systems and relevant legislation are still insufficient and lagging, even blank in som...

Authors: Xiaoting Zheng, Liyang Lyu, Hong Lu, Yuanjia Hu and Ging Chan

Anti-malarial drug: the emerging role of artemisinin and its derivatives in liver disease treatment

Artemisinin and its derivatives belong to a family of drugs approved for the treatment of malaria with known clinical safety and efficacy. In addition to its anti-malarial effect, artemisinin displays anti-vir...

Authors: Ye Xiong and Jianrong Huang

Correction to: West meets east: open up a dialogue on phytomedicine

Authors: Xiuzhu Li, Weijie Chen, Jesus Simal-Gandara, Milen I. Georgiev, Hongyi Li, Hao Hu, Xu Wu, Thomas Eferth and Shengpeng Wang

Traditional herbal formula Wu-Mei-Wan alleviates TNBS-induced colitis in mice by inhibiting necroptosis through increasing RIPK3 O-GlcNAcylation

Accumulating evidence indicated that necroptosis plays an essential role in the pathogenesis of inflammatory bowel disease (IBD). The O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) of necroptotic signal m...

Authors: Fan Wu, Qingqing Shao, Zhe Cheng, Xinyu Xiong, Ke Fang, Yan Zhao, Ruolan Dong, Lijun Xu, Fuer Lu and Guang Chen

Chaihu-Shugan-San (Shihosogansan) alleviates restraint stress-generated anxiety and depression in mice by regulating NF-κB-mediated BDNF expression through the modulation of gut microbiota

Chaihu-Shugan-San (CSS, named Shihosogansan in Korean), a Chinese traditional medicine, is frequently used to treat anxiety and depression. Psychiatric disorders including depression are associated with gut dy...

Authors: Sang-Kap Han, Jeon-Kyung Kim, Hee-Seo Park, Yeun-Jeong Shin and Dong-Hyun Kim

Herbal formula Huangqi Guizhi Wuwu decoction attenuates paclitaxel-related neurotoxicity via inhibition of inflammation and oxidative stress

Paclitaxel-induced peripheral neuropathy (PIPN) is a challenging clinical problem during chemotherapy. Our previous work found that herbal formula Huangqi Guizhi Wuwu decoction (HGWD) could reduce oxaliplatin-...

Authors: Zhangming Lv, Jiayun Shen, Xuejiao Gao, Yonglan Ruan, Jinying Ling, Rongwei Sun, Jingya Dai, Haizhen Fan, Xiaolan Cheng and Peng Cao

Systems pharmacology and transcriptomics reveal the mechanisms of Sanhuang decoction enema in the treatment of ulcerative colitis with additional Candida albicans infection

Ulcerative colitis (UC) is an important inflammatory phenotype in bowel disease (IBD), which is caused by multiple potential factors, including fungal dysbiosis. Candida albicans (C. albicans) was confirmed to be...

Authors: Zhijun Han, Xiaofen Tan, Juan Sun, Tianming Wang, Guiming Yan, Changzhong Wang and Kelong Ma

Flavonoids on diabetic nephropathy: advances and therapeutic opportunities

With the advances in biomedical technologies, natural products have attracted substantial public attention in the area of drug discovery. Flavonoids are a class of active natural products with a wide range of ...

Authors: Qichao Hu, Caiyan Qu, Xiaolin Xiao, Wenwen Zhang, Yinxiao Jiang, Zhao Wu, Dan Song, Xi Peng, Xiao Ma and YanLing Zhao

Traditional application and modern pharmacological research of Eucommia ulmoides Oliv.

As a Traditional Chinese Medicine, Eucommia ulmoides Oliv. has been used for the treatment of various diseases since ancient times, involving lumbar pain, knee pain, osteoporosis, hepatoprotection, paralysis, int...

Authors: Lichuang Huang, Qiang Lyu, Wanying Zheng, Qiao Yang and Gang Cao

Quinic acid: a potential antibiofilm agent against clinical resistant Pseudomonas aeruginosa

The biofilm state of pathogens facilitates antimicrobial resistance which makes difficult-to-treat infections. In this regard, it has been found that the compounds screened from plant extracts represent one ca...

Authors: Lan Lu, Yuting Zhao, Guojuan Yi, Mingxing Li, Li Liao, Chen Yang, Chihin Cho, Bin Zhang, Jie Zhu, Kun Zou and Qiang Cheng

Establishing a genomic database for the medicinal plants in the Brazilian Pharmacopoeia

Brazil is exceptionally abundant in medicinal plant resources and has a rich ethnopharmacological history. Brazilian Pharmacopoeia (BP) acts as a national standard that regulates drug quality and has six publi...

Authors: Guan-Ru Zhou, Bao-Sheng Liao, Qiu-Shi Li, Jiang Xu and Shi-Lin Chen

The key issues and development strategy of Chinese Classical Formulas pharmaceutical preparations

It is well-known that Prof. Tu Youyou won the Nobel Prize in Physiology or Medicine in 2015 due to the research on artemisinin treating malaria, and this can be regarded as the milestone of modernization of Tr...

Authors: Hua Luo, Hongguo Chen, Chang Liu, Siyuan Zhang, Chi Teng Vong, Dechao Tan, Yuntao Dai, Yitao Wang and Shilin Chen

Two methoxy derivatives of resveratrol, 3,3′,4,5′-tetramethoxy-trans-stilbene and 3,4′,5-trimethoxy-trans-stilbene, suppress lipopolysaccharide-induced inflammation through inactivation of MAPK and NF-κB pathways in RAW 264.7 cells

3,3′,4,5′-tetramethoxy-trans-stilbene (3,3′,4,5′-TMS) and 3,4′,5-trimethoxy-trans-stilbene (3,4′,5-TMS) are two methoxy derivatives of resveratrol. Previous researches have proved that resveratrol and its analogu...

Authors: Chunxiu Zhou, Xutao Zhang, Cheng-Chao Ruan and Wai San Cheang

Traditional Chinese Medicine in nonalcoholic fatty liver disease: molecular insights and therapeutic perspectives

Nonalcoholic fatty liver disease (NAFLD) has become the world's largest chronic liver disease, while there is still no specific drug to treat NAFLD. Traditional Chinese Medicine (TCM) have been widely used in ...

Authors: Xianmin Dai, Jiayi Feng, Yi Chen, Si Huang, Xiaofei Shi, Xia Liu and Yang Sun

Natural products provide a new perspective for anti-complement treatment of severe COVID-19: a review

Exaggerated immune response and cytokine storm are accounted for the severity of COVID-19, including organ dysfunction, especially progressive respiratory failure and generalized coagulopathy. Uncontrolled act...

Authors: Yadong Fan, Ying Wang, Shuang Yu, Jun Chang, Yiqi Yan, Yiyang Wang and Yuhong Bian

Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2

Idiopathic pulmonary fibrosis (IPF) is a serious chronic disease of the respiratory system, but its current treatment has certain shortcomings and adverse effects. In this study, we evaluate the antifibrotic a...

Authors: Yanfang Peng, Yingwen Zhang, Yabing Zhang, Xiuping Wang and Yukun Xia

Shenzhi Jiannao formula ameliorates vascular dementia in vivo and in vitro by inhibition glutamate neurotoxicity via promoting clathrin-mediated endocytosis

Synaptic damage and glutamate excitotoxicity have been implicated in the pathogenesis of vascular dementia (VD). Clathrin, RAB5B and N-methyl-d-aspartic acid receptor 1 (NMDAR1) proteins play a vital role in endo...

Authors: Danfeng Tian, Yangyang Guo, Dandan Zhang, Qiang Gao, Ganlu Liu, Jingfeng Lin, Ze Chang, Yuchun Wang, Rui Su and Zhenyun Han

Assessment of the reporting quality of randomised controlled trials of massage

To assess the reporting quality of randomised controlled trials (RCTs) of massage, particularly whether necessary elements related to massage interventions were adequately reported.

Authors: Xuan Zhang, Lin Zhang, Weifeng Xiong, Xihong Wang, Xiaohan Zhou, Chen Zhao, Guihua Tian, Hongcai Shang, Taixiang Wu, Jiangxia Miao and Zhaoxiang Bian

Current status of traditional Chinese medicine for the treatment of COVID-19 in China

An ongoing outbreak of severe respiratory illness and pneumonia caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) commenced in December 2019, and the disease was named as coronavirus disease 20...

Authors: Liang Chu, Fang Huang, Mengdan Zhang, Biao Huang and Yigang Wang

Herbal therapy for ameliorating nonalcoholic fatty liver disease via rebuilding the intestinal microecology

The worldwide prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing, and this metabolic disorder has been recognized as a severe threat to human health. A variety of chemical drugs have been app...

Authors: Xiao-Fang Yang, Ming Lu, Lijiao You, Huan Gen, Lin Yuan, Tianning Tian, Chun-Yu Li, Kailiang Xu, Jie Hou and Ming Lei

The toxicology and detoxification of Aconitum: traditional and modern views

Aconitum carmichaeli Debx.-derived herbal medicine has been used for anti-inflammation and anti-arrhythmia purpose for more than two thousand years. It is processed into Chuanwu (Radix Aconiti praeparata) and Fuz...

Authors: Yau-Tuen Chan, Ning Wang and Yibin Feng

Personalized bioconversion of Panax notoginseng saponins mediated by gut microbiota between two different diet-pattern healthy subjects

Panax notoginseng saponins (PNS) as the main effective substances from P. notoginseng with low bioavailability could be bio-converted by human gut microbiota. In our previous study, PNS metabolic variations media...

Authors: Li Wang, Man-Yun Chen, Li Shao, Wei Zhang, Xiang-Ping Li and Wei-Hua Huang

Insights into the molecular mechanisms of Huangqi decoction on liver fibrosis via computational systems pharmacology approaches

The traditional Chinese medicine Huangqi decoction (HQD) consists of Radix Astragali and Radix Glycyrrhizae in a ratio of 6: 1, which has been used for the treatment of liver fibrosis. In this study, we tried to ...

Authors: Biting Wang, Zengrui Wu, Weihua Li, Guixia Liu and Yun Tang

Corydalis saxicola Bunting total alkaloids attenuate paclitaxel-induced peripheral neuropathy through PKCε/p38 MAPK/TRPV1 signaling pathway

Corydalis saxicola Bunting, affiliated with the Papaveraceae Juss., has been proven to work well in anti-inflammation, hemostasis, and analgesia. This study was designed to observe the effect and potential mechan...

Authors: Chu Xue, Si-Xue Liu, Jie Hu, Jin Huang, Hong-Min Liu, Zhi-Xia Qiu and Fang Huang

West meets east: open up a dialogue on phytomedicine

The desire to extend the wisdom of traditional health systems has motivated the trade of many phytomedicine on a global scale for centuries, especially some dietary herbs, making a great overlap exits between ...

Authors: Xiuzhu Li, Weijie Chen, Jesus Simal-Gandara, Milen I. Georgiev, Hongyi Li, Hao Hu, Xu Wu, Thomas Efferth and Shengpeng Wang

The role of macrophage polarization and associated mechanisms in regulating the anti-inflammatory action of acupuncture: a literature review and perspectives

Acupuncture is used in the treatment of a variety of inflammatory conditions and diseases. However, the mechanisms of its anti-inflammatory action are complex and have not been systematically investigated. Mac...

Authors: Jiaqi Wang, Shanshan Lu, Fuming Yang, Yi Guo, Zelin Chen, Nannan Yu, Lin Yao, Jin Huang, Wen Fan, Zhifang Xu and Yinan Gong

Full-length transcriptome analysis reveals the mechanism of acupuncture at PC6 improves cardiac function in myocardial ischemia model

The pathological process of myocardial ischemia (MI) is very complicated. Acupuncture at PC6 has been proved to be effective against MI injury, but the mechanism remains unclear. This study investigated the me...

Authors: Jing Yuan, Jun-Meng Wang, Zhi-Wei Li, Cheng-Shun Zhang, Bin Cheng, Su-Hao Yang, Bai-Tong Liu, Li-Juan Zhu, Ding-Jun Cai and Shu-Guang Yu

Weight changes in hypertensive patients with phlegm-dampness syndrome: an integrated proteomics and metabolomics approach

Hypertension (HTN) patients who have phlegm-dampness syndrome (PDS) tend to be obese and have worse outcomes. However, the association of body weight (BW) changes and mechanisms underlying the pathophysiology ...

Authors: Chi Zhang, Li Li, Shiping Cheng, Debajyoti Chowdhury, Yong Tan, Xinru Liu, Ning Zhao, Xiaojuan He, Miao Jiang, Cheng Lu and Aiping Lyu

Global trends and prospects about inflammasomes in stroke: a bibliometric analysis

Sterile inflammation is a key pathological process in stroke. Inflammasome activation has been implicated in various inflammatory diseases, including ischemic stroke and hemorrhagic stroke. Hence, targeting in...

Authors: Junjun Yin, Jiayang Wan, Jiaqi Zhu, Guoying Zhou, Yuming Pan and Huifen Zhou

Plant super-barcode: a case study on genome-based identification for closely related species of Fritillaria

Although molecular analysis offers a wide range of options for species identification, a universal methodology for classifying and distinguishing closely related species remains elusive. This study validated t...

Authors: Lan Wu, Mingli Wu, Ning Cui, Li Xiang, Ying Li, Xiwen Li and Shilin Chen

UHPLC-QQQ-MS/MS assay for the quantification of dianthrones as potential toxic markers of Polygonum multiflorum Thunb: applications for the standardization of traditional Chinese medicines (TCMs) with endogenous toxicity

The raw and processed roots of Polygonum multiflorum Thunb (PM) are commonly used in clinical practice to treat diverse diseases; however, reports of hepatotoxicity induced by Polygoni Multiflori Radix (PMR) and ...

Authors: Jian-Bo Yang, Yun-Fei Song, Yue Liu, Hui-Yu Gao, Qi Wang, Ying Wang, Xian-Long Cheng, Tian-Tian Zuo, Xiao-Wen Hu, Feng Wei, Hong-Tao Jin, Shu-Ting Wang and Shuang-Cheng Ma

The combination of UHPLC-HRMS and molecular networking improving discovery efficiency of chemical components in Chinese Classical Formula

It is essential to identify the chemical components for the quality control methods establishment of Chinese Classical Formula (CCF). However, CCF are complex mixture of several herbal medicines with huge numb...

Authors: Xiaoxia Xue, Qishu Jiao, Runa Jin, Xueyuan Wang, Pengyue Li, Shougang Shi, Zhengjun Huang, Yuntao Dai and Shilin Chen

Honeysuckle-derived microRNA2911 inhibits tumor growth by targeting TGF-β1

Honeysuckle is a time‐honored herb with anticancer activity in traditional Chinese medicine. Recently, accumulating reports are suggesting that the microRNAs in this medicinal plant not only play a physiologic...

Authors: Chunyan Liu, Mengzhen Xu, Luocheng Yan, Yulian Wang, Zhen Zhou, Shaocong Wang, Yajie Sun, Junfeng Zhang and Lei Dong

Tanshinone I exerts cardiovascular protective effects in vivo and in vitro through inhibiting necroptosis via Akt/Nrf2 signaling pathway

Tanshinone I (TI) is a primary component of Salvia miltiorrhiza Bunge (Danshen), which confers a favorable role in a variety of pharmacological activities including cardiovascular protection. However, the exact m...

Authors: Youqiong Zhuo, Renyikun Yuan, Xinxin Chen, Jia He, Yangling Chen, Chenwei Zhang, Kaili Sun, Shilin Yang, Zhenjie Liu and Hongwei Gao

Cerebralcare Granule® enhances memantine hydrochloride efficacy in APP/PS1 mice by ameliorating amyloid pathology and cognitive functions

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory deficits and cognitive decline. Current drugs can only relieve symptoms, but cannot really cure AD. Cerebralcare Gran...

Authors: Ou Qiao, Xinyu Zhang, Yi Zhang, Haixia Ji, Zhi Li, Xiaoying Han, Wenzhe Wang, Xia Li, Juan Wang, Changxiao Liu and Wenyuan Gao

Zoology, chemical composition, pharmacology, quality control and future perspective of Musk (Moschus): a review

Musk, the dried secretion from the musk sac gland which is located between the navel and genitals of mature male musk deer, is utilized as oriental medicine in east Asia. It has been utilized to treat conditio...

Authors: Kai Liu, Long Xie, Mao Deng, Xumin Zhang, Jia Luo and Xiaofang Li

Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation

Panax notoginseng (Burk.) F. H. Chen (P. notoginseng) is a traditional Chinese medicine that has been used therapeutically for cardiovascular diseases, inflammatory diseases and traumatic injuries as well as for ...

Authors: Li Zhang, Qin Hu, Haonan Jin, Yongzhao Yang, Yan Yang, Renhua Yang, Zhiqiang Shen and Peng Chen

The three syndromes and six Chinese patent medicine study during the recovery phase of COVID-19

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), first broke out in Wuhan, China, in 2019. SARS-CoV-2 develops many types of mutations (such as B...

Authors: Xuedong An, Liyun Duan, Yue Hong Zhang, De Jin, Shenghui Zhao, Rong Rong Zhou, Yingying Duan, Fengmei Lian and Xiaolin Tong

Electroacupuncture reduces cold stress-induced pain through microglial inactivation and transient receptor potential V1 in mice

The treatment, and efficacy thereof, is considered to be inadequate with specificity to alleviation of Fibromyalgia and its associated pain. Fibromyalgia patients suffer from chronic and persistent widespread ...

Authors: Hsien-Yin Liao and Yi-Wen Lin

Identification of anti-inflammatory compounds from Zhongjing formulae by knowledge mining and high-content screening in a zebrafish model of inflammatory bowel diseases

Inflammatory bowel diseases (IBD) are chronic relapsing intestinal inflammations with increasing global incidence, and new drug development remains in urgent demand for IBD management. To identify effective tr...

Authors: Yunru Yu, Jing Chen, Xiaohui Zhang, Yingchao Wang, Shufang Wang, Lu Zhao and Yi Wang

Anti-angiogenesis and anti-metastasis effects of Polyphyllin VII on Hepatocellular carcinoma cells in vitro and in vivo

Polyphyllin VII (PP7), a steroidal saponin from P. polyphylla has been found to exert strong anticancer activity. Little is known about the anti-angiogenesis and anti-metastasis properties of PP7. In this study, ...

Authors: Chao Zhang, Qingrui Li, Guozheng Qin, Yi Zhang, Chaoying Li, Liwen Han, Rongchun Wang, Shudan Wang, Haixia Chen, Kechun Liu and Chengwei He