Bacterial endophytes are widespread inhabitants inside plant tissues that play crucial roles in plant growth and biotransformation. This study aimed to offer information for the exploitation of endophytes by a...
Cordyceps sinensis (C. sinensis) is a famous and precious Traditional Chinese Medicine (TCM), while frequent reports of heavy metals, especially arsenic, exceeding standards in C. sinensis in recent years have ra...
Ayurvedic medicine is based on natural healing methods that use herbal medicine to cleanse the body of toxins and to attain physical and mental regeneration. Triphala (TLP) is one of the most important ayurved...
Authors: Aleksandra Tarasiuk, Paula Mosińska and Jakub Fichna
The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used to treat acute pancreatitis for decades. DCQD could ameliorate the disease severity and the complications of organ injuries, including...
Siegesbeckia pubescens Makino (SP) is one of the important plant origins for the anti-inflammatory Chinese herbal medicine of Siegesbeckiae Herba. The current investigations indicated that the anti-inflammatory e...
Authors: Wei Sang, Zhangfeng Zhong, Kegang Linghu, Wei Xiong, Anfernee Kai Wing Tse, Wai San Cheang, Hua Yu and Yitao Wang
Cancer is still presenting a serious threat to human health worldwide. The understanding of the complex biology of cancer and the development of oncotherapy have led to increasing treatment approaches such as ...
Authors: Mu-Yang Huang, Le-Le Zhang, Jian Ding and Jin-Jian Lu
Idiopathic pulmonary fibrosis (IPF), a chronic, progressive, fibrosing interstitial lung disease, is associated with extremely poor prognosis, and lacks effective treatment. The frequently used immunosuppressi...
Authors: Chengliang Huang, Xu Wu, Shengpeng Wang, Wenjun Wang, Fang Guo, Yuanyuan Chen, Bi Pan, Ming Zhang and Xianming Fan
Cornus officinalis Sieb. et Zucc. is part of the genus Cornus of the family Cornaceae. Ripening and dry fruits (Corni Fructus) are recognized as an essential herb medicine in the traditional Chinese medicine (TCM...
Authors: Yu Dong, Zhe-Ling Feng, Hu-Biao Chen, Fu-Sheng Wang and Jia-Hong Lu
In recent years, studies of traditional medicinal plants have gradually increased worldwide because the natural sources and variety of such plants allow them to complement modern pharmacological approaches. As...
Authors: Fan Yi, Li Li, Li-jia Xu, Hong Meng, Yin-mao Dong, Hai-bo Liu and Pei-gen Xiao
Human placenta is used to make the medicinal product Placenta Hominis in Asian countries. With its therapeutic benefits and limited supply, intentional or inadvertent adulteration is found in the market. In or...
Authors: Yat-Tung Lo, Mavis Hong-Yu Yik and Pang-Chui Shaw
Autism spectrum disorders (ASD) is a common disease and the incidence has been rising constantly. Acupuncture is one of the most widely used complementary and alternative medicine therapies. Despite studies ha...
Authors: Chuen Heung Yau, Cheuk Long Ip and Yuk Yin Chau
Illicium plants are relevant officinal and ornamental species that are native in Eastern Asia, and they are the main sources of shikimic acid. Shikimic acid is an important component of Tamiflu, which is recogniz...
Authors: Xiang Zhang, Xiangxiao Meng, Jie Wu, Linfang Huang and Shilin Chen
Complicated with the impact of aging population and urbanization, coronary heart disease (CHD) incurs more and more disease burdens in China. Salvianolate injection is a Chinese patent drug widely used for tre...
Authors: Pengxin Dong, Hao Hu, Xiaodong Guan, Carolina Oi Lam Ung, Luwen Shi, Sheng Han and Shuwen Yu
Rhizoma coptidis has been used in China for thousands of years with the functions of heating dampness and purging fire detoxification. But the underlying molecular mechanisms of Rhizoma coptidis are still far ...
Authors: Jin Wang, Qian Ran, Hai-rong Zeng, Lin Wang, Chang-jiang Hu and Qin-wan Huang
Houzao (bezoar) is a valuable imported Chinese medicine that is commonly used as a pediatric medicine to transform phlegm. There are mainly two types of Houzao, “Southeast Asian Houzao” and “Indian Houzao”. “I...
Authors: Zhongzhen Zhao, Eric Brand, Hiu Yee Kwan, Quanbin Han and Mengjia Zhou
The modernization and internationalization of Chinese medicines (CMs) are hampered by increasing concerns on the safety and the efficacy. Pharmacokinetic (PK) study is indispensable to establish concentration-...
Triptolide, an active ingredient of Chinese medicine plant Tripterygium wilfordii Hook.f., has been shown to exert anti-tumor, immunosuppressive, anti-inflammatory, and anti-fertility pharmacological effects. How...
Authors: Yuan Wei, Dujun Wang, Meng Chen, Zhen Ouyang, Shuo Wang and Jun Gu
Urera aurantiaca is an Argentinean species that has been traditionally used to treat symptoms of inflammation. The aim of this study was to determine and compare the anti-inflammatory and antioxidant effects of t...
Authors: Carla Marrassini, Ignacio Peralta and Claudia Anesini
Eosinophils (EOS) is one of the most important cells involved in the pathogenesis of chronic airway inflammation in asthma, and its apoptosis is part of the mechanisms of asthma. Therefore, this study aimed to...
Authors: Yue Yan, Hai-Peng Bao, Chun-Lei Li, Qi Shi, Yan-Hua Kong, Ting Yao and You-Lin Li
Natural medicines were the only option for the prevention and treatment of human diseases for thousands of years. Natural products are important sources for drug development. The amounts of bioactive natural p...
Authors: Qing-Wen Zhang, Li-Gen Lin and Wen-Cai Ye
Cordyceps sinensis, one of the most valued traditional herbal medicines in China, contains high amount of arsenic. Considering the adverse health effects of arsenic, this is of particular concern. The aim of this...
Authors: Tian-Tian Zuo, Yao-Lei Li, Hong-Yu Jin, Fei Gao, Qi Wang, Ya-Dan Wang and Shuang-Cheng Ma
Books that record the sources and applications of medicinal materials are commonly known as bencao (materia medica) in China. Bencao (materia medica) literature review is the very first step in the standard authe...
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs. So far, no Western medicine treatment can completely inhibit or reverse the progress of SSc, while a...
Authors: Qian Wang, Wenhua Zang, Li Han, Lei Yang, Songshan Ye, Jingfeng Ouyang, Chaoyun Zhang, Yuefeng Bi, Cuiyue Zhang and Hua Bian
Psoriasis is a chronic, painful, disfiguring and non-contagious skin disease that has globally affected at least 200 million patients. In general, mild to moderate psoriasis patients will be treated by chemica...
Authors: Shikang Meng, Zibei Lin, Yan Wang, Zhenping Wang, Ping Li and Ying Zheng
Investigating the pharmacology is key to the modernization of Chinese Medicine (CM) formulas. However, identifying which are the active compound(s) of CM formulas, which biological entities they target, and th...
Authors: Tao Huang, Linda L. D. Zhong, Chen-Yuan Lin, Ling Zhao, Zi-Wan Ning, Dong-Dong Hu, Man Zhang, Ke Tian, Chung-Wah Cheng and Zhao-Xiang Bian
Cerebral hypoperfusion is a pivotal risk factor for vascular dementia (VD), for which effective therapy remains inadequate. Persistent inflammatory responses and excessive chemotaxis of microglia/macrophages i...
Authors: Xian-Qin Luo, Ao Li, Xue Yang, Xiao Xiao, Rong Hu, Tian-Wen Wang, Xiao-Yun Dou, Da-Jian Yang and Zhi Dong
Coptidis rhizoma (CR) is the dried rhizome of Coptis chinensis Franch., C. deltoidea C. Y. Cheng et Hsiao or C. teeta Wall. (Ranunculaceae) and is commonly used in Traditional Chinese Medicine for the treatment o...
Authors: Fan-Cheng Meng, Zheng-Feng Wu, Zhi-Qi Yin, Li-Gen Lin, Ruibing Wang and Qing-Wen Zhang
Action (“gongxiao” in Chinese) of traditional Chinese medicine (TCM) is the high recapitulation for therapeutic and health-preserving effects under the guidance of TCM theory. TCM-defined herbal properties (“yaox...
Authors: Zhao Chen, Yanfeng Cao, Shuaibing He and Yanjiang Qiao
Melanoma is a leading cause of cancer death worldwide, and SMI-4a and G-Rh2 exert anti-tumor activity in multiple cancer. However, SMI-4a as well as a synergistic relationship between SMI-4a and G-Rh2 in anti-...
Authors: Da-lun Lv, Lei Chen, Wei Ding, Wei Zhang, He–li Wang, Shuai Wang and Wen-bei Liu
Amomum compactum is one of the basic species of the traditional herbal medicine amomi fructus rotundus, with great pharmacology effect. The system position of A. compactum is not clear yet, and the introduction o...
Authors: Ming-li Wu, Qing Li, Jiang Xu and Xi-wen Li
Through reviewing the current international market for traditional Chinese medicine (TCM), this paper identified the internationalization challenges for TCM, including unclear therapeutic material basis and me...
Authors: Annie Xianghong Lin, Ging Chan, Yuanjia Hu, Defang Ouyang, Carolina Oi Lam Ung, Luwen Shi and Hao Hu
Rhizoma Paridis (Chonglou) is a commonly used and precious traditional Chinese medicine. Paris polyphylla Smith var. yunnanensis (Franch.) Hand. -Mazz. and Paris polyphylla Smith var. chinensis (Franch.) Hara are...
Authors: Bao-Zhong Duan, Ya-Ping Wang, Hai-Lan Fang, Chao Xiong, Xi-Wen Li, Ping Wang and Shi-Lin Chen
Functional polysaccharides can be derived from plants (including herbs), animals and microorganisms. They have been widely used in a broad of biomedical applications, such as immunoregulatory agents or drug de...
Authors: Qiu Li, Yiming Niu, Panfei Xing and Chunming Wang
To determine the effect of Shuganyin decoction (SGD) on the intestinal barrier function in an irritable bowel syndrome (IBS) rat model induced by water-avoidance stress.
Authors: Lu Lu, Liang Yan, Jianye Yuan, Qing Ye and Jiang Lin
Traditional Chinese medicine (TCM) is currently the best-preserved and most influential traditional medical system with the largest number of users worldwide. In recent years, the trend of TCM adoption has inc...
Authors: Haitao Tang, Wenlong Huang, Jimei Ma and Li Liu
Processing (Paozhi) represents a unique Chinese pharmaceutic technique to facilitate the use of Chinese herbal medicines (CHMs) for a specific clinical need in the guidance of Traditional Chinese Medicine (TCM) t...
Authors: Xu Wu, Shengpeng Wang, Junrong Lu, Yong Jing, Mingxing Li, Jiliang Cao, Baolin Bian and Changjiang Hu
Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed the Tmax of Tripterygium wilfordii (TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the...
Zhibai Dihuang Granule (ZDG) is a traditional Chinese medicine which has been used to treat Yin-deficiency-heat (YDH) syndrome for thousands of years in China. However, little work has been conducted to explor...
Authors: Chang-Ming Liu, Jing Chen, Su Yang, Ting-Ting Jiang, Zhong-Liang Chen, Hui-Hui Tu, Lian-Gen Mao, Yu-Ting Hu, Lin Gan, Zhong-Jie Li and Ji-Cheng Li
Rhubarb is one of the most ancient, commonly used and important herbs in Chinese medicine. The modern researches of rhubarb clarified the efficacies, ingredients and mechanisms in a more scientific and rigorou...
Authors: Yu-Jie Cao, Zong-Jin Pu, Yu-Ping Tang, Juan Shen, Yan-Yan Chen, An Kang, Gui-Sheng Zhou and Jin-Ao Duan
Dysfunctional metabolisms are contributed to LPS/GALN-induced hepatitis. However, whether Hedyotis diffusa (HD) employs metabolic strategies against hepatitis is unknown.
Authors: Min Dai, Fenglin Wang, Zengcheng Zou, Gemin Xiao, Hongjie Chen and Hongzhi Yang
Nowadays, Radix Polygoni Multiflori (RPM, Heshouwu in Chinese) from different geographical origins were used in clinic. In order to characterize the chemical profiles of different geographical origins of RPM s...
Authors: Jin-Fa Tang, Wei-Xia Li, Fan Zhang, Yu-Hui Li, Ying-Jie Cao, Ya Zhao, Xue-Lin Li and Zhi-Jie Ma
The non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. In NSCLC, the oncogenic AKT-mTOR, ERK and STAT3 pathways are commonly dysregulated and have emerged as attractive targets ...
Authors: I-Chun Lai, Gi-Ming Lai, Jyh-Ming Chow, Hsin-Lun Lee, Chuan-Feng Yeh, Chi-Han Li, Jiann-Long Yan, Shuang-En Chuang, Jacqueline Whang-Peng, Kuan-Jen Bai and Chih-Jung Yao
Wound ointment (WO), a kind of Chinese medicine, can significantly promote fracture healing. The study aimed at analyzing the chemical composition and the effects of WO on fracture of rabbits and tried to expl...
Authors: Zhixue Ou, Qi Cheng, Yueping Chen, Tao Chen, Xiangbin Rong, Feipan Long, Xiaoyun Zhang, Qinghua Liang and Zhe Feng
Penthorum chinense Pursh (Penthoraceae, PCP), a well-known Miao ethnomedicine, has been traditionally used to treat several liver-related diseases, such as jaundice and viral hepatitis...
Authors: Meng Wang, Xiao-Jiao Zhang, Ruibing Feng, Yun Jiang, Da-Yong Zhang, Chengwei He, Peng Li and Jian-Bo Wan
Stroke is the second most common cause of death and may result in various disabilities; thus, identification of neuroprotective therapeutic agents is important. Peucedani Radix (PR), the root of Angelica decursiv...
Authors: So-Youn Jung, Kyoung-Min Kim, Suin Cho, Sehyun Lim, Chiyeon Lim and Young Kyun Kim
The dried root of Salvia miltiorrhiza, Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and Korea. In Asian traditional medicine, SR is considered to h...
Authors: Chiyeon Lim, Sehyun Lim, Byoungho Lee, Buyeo Kim and Suin Cho
