Recent advances in the investigation of curcuminoids

Chinese Medicine

Table 3 Anti-HIV integrase activity data of curcumin derivatives

Compound	R₁	R₂	R₃	R₄	3-processing IC₅₀ (μM)	Strand transfer IC₅₀ (μM)
2	OCH₃	OH	OCH₃	OH	150	140
3	H	OH	H	OH	120	80 ± 20
4	H	OH	OCH₃	OH	140	120
9	structure formula 9 above				>300	>300
12	H	H	H	H	>300	>300
20	H	OCH₃	H	OCH₃	>300	>300
35	OH	OH	OH	OH	6.0 ± 1.5	3.1 ± 0.12
36	OCH₃	OH	OH	OH	18.0 ± 9.0	9.0 ± 3.0
37	structure formula 37 above				9 ± 7	4.0 ± 1.5

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