Hepatoprotective effect of ethanolic extract of Trichosanthes lobata on paracetamol-induced liver toxicity in rats

Table 2 Serum biochemical parameters

Parameter	Groups (n = 6 for each group)
	Control (Group I)	Paracetamol	Paracetamol +	Ethanolic Extract of *Trichosanthes lobata*
	Control (Group I)	2 g/kg body weight (Group II)	silymarin 100 mg/kg body weight (Group III)	200 mg/kg body weight (Group IV)	400 mg/kg body weight (Group V)
AST (U/l)	37.67 (3.803)	127.3 (25.51)^a	30.83 (7.705)^a	32.00 (6.899)^a	18.50 (9.182)^a
ALT (U/l)	21.67 (1.966)	146.3 (32.38)^a	68.17 (22.44)^a	64.00 (9.011)^b	37.50 (6.686)^ns
ALP (U/l)	187.2 (20.23)	312.0 (62.24)^a	204.5 (55.56)^a	210.7 (30.75)^b	171.80 (19.16)^a
Bilurubin (mg/dl)	0.63 (0.2160)	1.10 (0.2191)^b	0.40 (0.2608)^a	0.35 (0.1871)^a	0.23 (0.1033)^a
Total protein (g/dl)	1.80 (0.4011)	2.03(0.0811)^ns	1.83 (0.3084)^ns	1.77 (0.3830)^ns	2.11 (0.3147)^ns

a, P < 0.001; b, P < 0.01; ns : non significant.
Values are expressed as mean (standard deviation; SD). Statistical significance was calculated with ANOVA followed by Dunnett test comparing treated group with paracetamol group.

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