Group | Day 3 | Day 4 | Day 5 |
---|
Control | 36.80 ± 12.60 | 32.87 ± 15.5 | 27.53 ± 14.21 |
APP | 50.33 ± 9.39▲▲ | 47.73 ± 8.65▲▲ | 44.87 ± 11.98▲▲ |
APP + D | 38.25 ± 14.41● | 34.42 ± 12.84● | 30.58 ± 15.42● |
APP + Gl | 40.93 ± 14.11 | 36.93 ± 13.78● | 35.00 ± 15.75 |
APP + Gm | 42.92 ± 13.05 | 38.58 ± 14.15 | 31.42 ± 14.80● |
APP + Gh | 38.45 ± 14.12● | 35.27 ± 14.01● | 30.91 ± 13.01● |
- The effects of GEPT on escape latency in 7-month-old mice (n = 12) were assessed in orientation navigation tests using the Morris Water Maze (MWM). Data are expressed as mean ± standard deviation (SD). Control: C57BL/6 J mice; APP: APPV717I mice; APP + D: APP mice treated with donepezil; APP + Gl: APP mice treated with GEPT (low dose); APP + Gm: APP mice treated with GEPT (medium dose); APP + Gh: APP mice treated with GEPT (high dose). P < 0.05 vs. APP mice alone; ▴▴P < 0.01 vs. control mice, one-way ANOVA.