Figure 1

Histopathologic sections of the liver in the CCl ₄ -induced model. (Group I) Liver sections of normal healthy mice show normal arrangements of cells in the liver lobules. (Group II) Hepatocyte necrosis and evident vacuolation of hepatocytes are observed in liver sections of CCl₄-treated mice. (Group III and Group IV) Liver sections of mice pretreated with bifendate at 0.40 g/kg body weight (Group III) or SRF at 0.05 g/kg body weight (Group IV) show mild vacuolation of hepatocytes. (Group V) Mice pretreated with SRF (0.10 mg/kg body weight) show very mild hepatocyte necrosis and mild vacuolation of hepatocytes. (Group VI) Liver sections of mice pretreated with SRF (0.20 mg/kg body weight) show marked improvement in the histology compared with the CCl₄-treated control group. HE staining; 100× magnification.