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Table 2 The genotoxic, cytostatic, and cytotoxic potential of apigenin

From: Time course changes of anti- and pro-apoptotic proteins in apigenin-induced genotoxicity

Agents

SCEs/chromosome ± SD (range of values)

PRI

MI (‰)

Untreated control

0.17 ± 0.08 (0.04-0.42)

2.64 ± 0.03

76.3 ± 9.50

Vehicle control

0.15 ± 0.08 (0.03-0.33)

2.65 ± 0.06

87.3 ± 20.20

AP (1 μM)

0.15 ± 0.09 (0.04-0.42)

2.61 ± 0.10

63.0 ± 19.52

ΑP (10 μΜ)

0.22 ± 0.14*,a (0.03-0.69)

2.52 ± 0.13

57.0 ± 22.84

AP (20 μΜ)

0.26 ± 0.12*,b,c (0.07-0.64)

2.09 ± 0.12*,d

32.7 ± 7.96*

ΑP (50 μΜ)

ND

ND

9.3 ± 7.57*,e

  1. *P ≤ 0.01 vs. vehicle control; aP < 0.01 vs. 1 μM; bP < 0.001 vs. 1 μM; cP < 0.05 vs. 10 μΜ; dP ≤ 0.001 vs. 1 and 10 μΜ; eP < 0.01 vs. 1, 10 and 20 μM. ND: values could not be determined.