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Table 2 Minimum inhibitory concentrations (MICs) and minimum microbicidal concentrations (MMCs) of the B. marginatum extracts against different pathogens determined by the broth microdilution method

From: Anti-infective and cytotoxic properties of Bupleurum marginatum

Microorganisms CH3OH extract mg/mL CH2Cl2extract mg/mL Ampicillin μg/mL Vancomycin μg/mL Nystatin μg/mL
MIC MMC MIC MMC MIC MMC MIC MMC MIC MMC
Gram positive           
 MRSA 818014 4 > 4 4 > 4 6.2 6.2 0.8 0.8 NT NT
 MRSA 818081 4 > 4 4 > 4 6.2 50 0.8 0.8 NT NT
 MRSA NCTC 10442 4 > 4 4 > 4 6.2 12.5 0.8 1.6 NT NT
Staphylococcus aureus ATCC 29213 4 > 4 4 > 4 0.4 3.1 0.4 0.8 NT NT
Staphylococcus epidermidis ATCC 14990 2 > 4 2 > 4 0.4 0.8 0.8 1.6 NT NT
Streptococcus pyogenes ATCC 12344 0.5 4 0.25 0.75 0.1 0.1 0.1 0.2 NT NT
Streptococcus agalactiae ATCC 27956 0.5 4 0.5 4 0.1 0.2 0.4 0.4 NT NT
Bacillus subtilis ATCC 6051 0.5 2 0.5 1 0.1 0.8 0.2 0.8 NT NT
Gram negative           
Pseudomonas aeruginosa ATCC 27853 4 > 4 4 > 4 NI NI NI NI NT NT
Escherichia coli ATCC 25922 2 4 4 > 4 6.2 12.5 NI NI NT NT
Fungi           
Candida albicans ATCC 90028 NI NT NI NT NT NT NT NT 1.6 1.6
Candida glabrata ATCC MYA 2950 NI NT NI NT NT NT NT NT 1.6 1.6
  1. NI: no inhibition; NT: not tested.