Table 2 Minimum inhibitory concentrations (MICs) and minimum microbicidal concentrations (MMCs) of the B. marginatum extracts against different pathogens determined by the broth microdilution method
From: Anti-infective and cytotoxic properties of Bupleurum marginatum
Microorganisms | CH3OH extract mg/mL | CH2Cl2extract mg/mL | Ampicillin μg/mL | Vancomycin μg/mL | Nystatin μg/mL | |||||
|---|---|---|---|---|---|---|---|---|---|---|
MIC | MMC | MIC | MMC | MIC | MMC | MIC | MMC | MIC | MMC | |
Gram positive | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 MRSA 818014 | 4 | > 4 | 4 | > 4 | 6.2 | 6.2 | 0.8 | 0.8 | NT | NT |
 MRSA 818081 | 4 | > 4 | 4 | > 4 | 6.2 | 50 | 0.8 | 0.8 | NT | NT |
 MRSA NCTC 10442 | 4 | > 4 | 4 | > 4 | 6.2 | 12.5 | 0.8 | 1.6 | NT | NT |
 Staphylococcus aureus ATCC 29213 | 4 | > 4 | 4 | > 4 | 0.4 | 3.1 | 0.4 | 0.8 | NT | NT |
 Staphylococcus epidermidis ATCC 14990 | 2 | > 4 | 2 | > 4 | 0.4 | 0.8 | 0.8 | 1.6 | NT | NT |
 Streptococcus pyogenes ATCC 12344 | 0.5 | 4 | 0.25 | 0.75 | 0.1 | 0.1 | 0.1 | 0.2 | NT | NT |
 Streptococcus agalactiae ATCC 27956 | 0.5 | 4 | 0.5 | 4 | 0.1 | 0.2 | 0.4 | 0.4 | NT | NT |
 Bacillus subtilis ATCC 6051 | 0.5 | 2 | 0.5 | 1 | 0.1 | 0.8 | 0.2 | 0.8 | NT | NT |
Gram negative | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Pseudomonas aeruginosa ATCC 27853 | 4 | > 4 | 4 | > 4 | NI | NI | NI | NI | NT | NT |
 Escherichia coli ATCC 25922 | 2 | 4 | 4 | > 4 | 6.2 | 12.5 | NI | NI | NT | NT |
Fungi | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Candida albicans ATCC 90028 | NI | NT | NI | NT | NT | NT | NT | NT | 1.6 | 1.6 |
 Candida glabrata ATCC MYA 2950 | NI | NT | NI | NT | NT | NT | NT | NT | 1.6 | 1.6 |