From: Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials
Author (year) | Sample size | Interventions (regimen) | Control (regimen) | Outcomes | Intergroup differences | Adverse events |
---|---|---|---|---|---|---|
Conditions | ||||||
Age (years) | ||||||
Diagnosis criteria | ||||||
Wu et al. (2009) [14] | 81 | (A) QZR (decoction, 200 ml daily for 24 wks, n = 40) | (B) Haloperidol and trihexyphenidyl (50 μg/kg, n = 41) | (1) YGTSS Score | (1) MD −20.73 [−21.8, –19.66], P < 0.05 | (A) Loss of appetite |
Children with tic disorder | ||||||
8–10 | ||||||
66/15 | ||||||
DSM-IV criteria | ||||||
(2) Effective rate | (2) RR 1.72[1.32, 2.25], P < 0.05 | (B) Weight gain and drowsiness | ||||
Wu et al. (2010) [15] | 61 | (A) QZR (decoction, 200 ml daily for 24 wks, n = 31) | (B) Haloperidol and trihexyphenidyl (50 μg/kg, n =30) | (1) YGTSS Score | (1) MD −15.9 [−17.31, −14.49], P < 0.05 | (A) Loss of appetite |
Children with tic disorder | ||||||
51/10 | ||||||
DSM-IV criteria | ||||||
(2) Effective rate | (2) RR 1.65[1.23, 2.21], P < 0.05 | (B) Weight gain and drowsiness | ||||
Zhao et al. (2010) [16] | 64 | (A) ND (granule capsule, 1 g daily for 8 wks, n = 33) | (B) Placebo (n = 31) | (1) YGTSS Score | (1) MD −6.52 [−9.8, –3.24], P < 0.001 | (A) Loss of appetite, constipation |
(2) Effective rate | (2) RR4.3 [ 1.68, 11.0], P < 0.001 | (B) None | ||||
Children with Tourette’s syndrome | ||||||
7–18 | ||||||
57/7 | ||||||
DSM-IV criteria | ||||||
Li et al. (2009) [17] | 90 | (A) ND (granules, 3–9 g daily for 24 wks, n = 60), plus (B) | (B) Haloperidol (2–6 mg, n = 30) | (1) YGTSS Score | (1) MD −4.35 [−7.34, –1.36], P < 0.01 | (A) and (B) Drowsiness, lassitude, poor appetite |
Children with Tourette’s syndrome | ||||||
(2) Effective rate | (2) RR1.3 [ 1.04, 1.62], P < 0.01 | |||||
6–13 | ||||||
70/20 | ||||||
DSM-IV criteria |