Effects of LicA on the T0901317-stimulated activation of LXRE-containing promoters. LXRα-mediated transcriptional activity was determined on (A) 3 × LXRE-luciferase or (B) SREBP-1c LXRE-luciferase reporters in the presence of 1 μM T0901317 and 10 μg/mL LicA in HepG2 cells. Luciferase activity was normalized to cotransfected β-galactosidase activity. Data were presented as means (SD) from four independent experiments with duplicate determinations. Statistical analysis was performed using one-way ANOVA. P* = P value for Bonferroni correction. DMSO, dimethyl sulfoxide; T1317, T0901317.