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Fig. 8 | Chinese Medicine

Fig. 8

From: Panax Notoginseng flower saponins (PNFS) inhibit LPS-stimulated NO overproduction and iNOS gene overexpression via the suppression of TLR4-mediated MAPK/NF-kappa B signaling pathways in RAW264.7 macrophages

Fig. 8

PNFS significantly inhibited the activation of LPS-stimulated NF-kappaB signaling pathway in RAW264.7 macrophages. a PNFS inhibited the IkappaBalpha activation in LPS-stimulated RAW264.7 macrophages. b PNFS inhibited the P65 activation in LPS-stimulated RAW264.7 macrophages. Data of the production of P-IkappaBalpha, total IkappaBalpha, P-P65 and total P65 were all expressed as the mean (SD) of 3 independent experiments. One-Way ANOVA test was used to analyzed the data and the results were F = 11.172; P = 0.009, F = 0.146; P = 0.867, F = 8.793; P = 0.016 and F = 0.062; P = 0.941, respectively. Then, data of the production of P-IkappaBalpha, total IkappaBalpha, P-P65 and total P65 were all counted by SNK and LSD multiple comparisons to determine the statistical difference between two groups. The P values represented the statistical differences between each group and the corresponding positive control (without PNFS and with LPS treated). * means P < 0.05 and ** means P < 0.01

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Chinese Medicine

ISSN: 1749-8546

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