Effect of Xiaoyaosan on major depressive disorder

Chinese Medicine

Table 1 Summary of published clinical trials on XYS in the treatment of MDD

Study ID	Sample size	Diagnostic criteria	Trial design				Course (weeks)	Follow-up (months)	Major outcomes
Study ID	Sample size	Diagnostic criteria	Intervention	Control	Randomizer	Blindness	Course (weeks)	Follow-up (months)	Efficacy by HAMD	Clinical efficacy	Side effects	Relapse	Onset time
Xian et al. [6]	60	CCMD-3	XYS decoction	Fluoxetine	Random number table	Single	6	N/A	N/A	↑	↓	N/A	N/A
Zhang et al. [8]	110	Depression Inventory (DI)	Xiaoyao pill	Placebo	Random number table	Double	8	N/A	N/A	↑ (DI)	N/A	N/A	N/A
Feng et al. [7]	58	CCMD-3	XYS decoction	N/A	N/A	N/A	8	N/A	↑	↑(CGI)	N/A	N/A	N/A

CCMD China classification and diagnostic criteria for mental disorder, HAMD Hamilton depression scale, CGI clinical global impression, N/A not available, ↑ significant increase compared with control, ↓ significant decrease compared with control.

ISSN: 1749-8546