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Table 1 Summary of published clinical trials on XYS in the treatment of MDD

From: Effect of Xiaoyaosan on major depressive disorder

Study ID Sample size Diagnostic criteria Trial design Course (weeks) Follow-up (months) Major outcomes
Intervention Control Randomizer Blindness Efficacy by HAMD Clinical efficacy Side effects Relapse Onset time
Xian et al. [6] 60 CCMD-3 XYS decoction Fluoxetine Random number table Single 6 N/A N/A N/A N/A
Zhang et al. [8] 110 Depression Inventory (DI) Xiaoyao pill Placebo Random number table Double 8 N/A N/A ↑ (DI) N/A N/A N/A
Feng et al. [7] 58 CCMD-3 XYS decoction N/A N/A N/A 8 N/A ↑(CGI) N/A N/A N/A
  1. CCMD China classification and diagnostic criteria for mental disorder, HAMD Hamilton depression scale, CGI clinical global impression, N/A not available, ↑ significant increase compared with control, ↓ significant decrease compared with control.