Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms

Table 1 Compounds in EXD satisfying LR, OB ≥30% and DL ≥0.18

	Herbs
	HE	RC	RMO	RAS	CPC	RA
Number of compounds	150	104	189	173	63	81
Compounds (percentage) passing LR	75 (50.0%)	29 (27.9%)	125 (66.1%)	131 (75.7%)	43 (68.3%)	45 (55.6%)
Compounds (percentage) with OB ≥30% and DL ≥0.18	23 (15.3%)	7 (6.7%)	20 (10.6%)	5 (2.9%)	28 (44.4%)	15 (18.5%)
Compounds (percentage) satisfying LR, OB ≥30% and DL ≥0.18	17 (11.3%)	4 (3.8%)	12 (6.3%)	3 (1.7%)	19 (30.2%)	11 (13.6%)

LR Lipinski’s rule, OB oral bioavailability, DL drug-likeness index, HE Herba Epimedium Brevicornum, RC Rhizoma Curculiginis Orchioides, RMO Radix Morindae Officinalis, RAS Radix Angelicae Sinensis, CPC Cortex Phellodendri Chinensis, RA Rhizoma Anemarrhenae asphodeloides.

ISSN: 1749-8546