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Table 3 Effects of CTS on body weight, liver weight, and adipose tissue weight of mice fed with HFD

From: Crude triterpenoid saponins from Ilex latifolia (Da Ye Dong Qing) ameliorate lipid accumulation by inhibiting SREBP expression via activation of AMPK in a non-alcoholic fatty liver disease model

Parameter Control HFD HFD + Simvastatin HFD + CTS-100 HFD + CTS-200
Initial body weight (g) 21.10 ± 1.62 21.22 ± 1.21 20.31 ± 1.03 21.56 ± 2.02 21.64 ± 1.36
Final body weight (g) 30.35 ± 3.06 40.39 ± 3.02## 35.63 ± 4.63 37.97 ± 4.13* 37.68 ± 2.91*
Body weight gain (g) 9.25 ± 0.91 19.17 ± 0.32# 15.32 ± 0.53 16.41 ± 0.44* 14.89 ± 0.46*
Adipose tissuea weight (g) 0.96 ± 0.23 1.67 ± 0.49## 1.24 ± 0.29 1.37 ± 0.64 1.43 ± 0.54*
Ratio of adipose tissue and body weight (%) 3.22 ± 0.90 4.29 ± 1.55## 3.51 ± 1.49 3.67 ± 2.16 3.84 ± 1.46*
Liver weight (g) 1.45 ± 0.14 2.26 ± 0.17## 2.02 ± 0.39 2.15 ± 0.22 2.09 ± 0.39**
Ratio of liver and body weight (%) 4.81 ± 0.60 5.74 ± 0.71## 5.50 ± 1.47 5.70 ± 0.70 5.63 ± 1.30*
  1. Adipose tissuea: including omental adipose tissue, perirenal adipose tissue, and epididymal adipose tissue.
  2. Values were expressed as the mean ± SD (n = 10). # P < 0.05, ## P < 0.01, HFD vs. control. P < 0.05, P < 0.01, HFD vs. simvastatin treatment. *P < 0.05, **P < 0.01, HFD vs. CTS treatment.