Table 1 Basic information of the isoquinoline alkaloids in M. cordata
No. | Compounds | Bioactivities | Virtual hitting targets |
|---|---|---|---|
1 | 6-Acetonyl-dihydrosanguinarine | Anti-bacteria Insecticidal | MIF; TTR; NQO1 |
2 | 6-Acetonyl-dihydrochelerythrine | Anti-oxidant Anti-HIV | HSD1; MIF; PDE4D; NQO1; PLA2s; nAChR 7α; AknH; TtgR |
3 | 6-Methoxy-dihydrochelerythrine | Anti-cancer Anti-parasitic | CAR/RXR; MR; ERα; JNK3; SHBG; AR; 15S-LOX; MMP12; PPARγ; SARS M(pro); Scy D; MAO-A |
4 | 6-Methoxy-dihydrosanguinarine | Anti-bacteria Anti-cancer Anti-platelet aggregation | MR; ERα; FNR; MAO-A |
5 | Bocconoline | Anti-bacteria Anti-fungal | Opsin 2; HSD1; CAR/RXR; MD; ERα; JNK3; SHBG; Chk1; AR; 15S-LOX; CDK2; CAMKII; Aurora A; PIM1; MMP12; Tankyrase 2; SARS M(pro); PfENR; FabZ; DHODH; CDPKs; FNR; ENR; Scy D; MAO-A |
6 | Dihydrochelerythrine | Anti-bacteria Anti-fungal | CAR/RXR; MR; ERα; PPO; TTR; JNK3; SHBG; NQO1; RBP4; 15S-LOX; CK2; PIM1; FabZ; DHODH; SnoaL; FNR; ENR; Scy D; MAO-A; MAO-B; AchE; HIV-1 RT; OSBP |
7 | Dihydrosanguinarine | Anti-bacteria Anti-fungal | MR; ERα; PPO; SHBG; 15S-LOX; CDK2; CK2; MAO-A; AchE |
8 | Oxysanguinarine | Anti-platelet aggregation | PIM1; CK2 |
9 | Oxychelerythrine | Cytotoxic | CAR/RXR; TTR; JNK3; SHBG; 15S-LOX; CLK1; CK2; PIM1; MMP12; MAPK p38; COMP; FabZ; SonaL; FNR; ENR; MAO-A; MAO-B; AchE; OSBP |
10 | Norsanguinarine | Anti-fungal | CK2; NmrA |
11 | 6-ethoxychelerythrine | Anti-bacteria Anti-fungal | MIF; TTR; JNK3; GAPDH; nAChR 7α; FabZ; CAT; LmrR; HS5B Pol |
12 | Chelerythrine | Anti-bacteria Anti-fungal Anti-parasitic Anti-cancer | MIF; TTR; FabZ; HS5B Pol |
13 | Chelirubine | Anti-proliferative | MIF; NQO1; GR; ZipA-FtsZ; AknH; opdA |
14 | Macarpine | Cytotoxic Anti-proliferative | PDE4B; PDE 4B; MIF; TTR; NQO1; PIM1; MAPK p38; GR; ZipA-FtsZ; AknH |
15 | Sanguinarine | Anti-bacteria Anti-fungal Anti-parasitic Anti-cancer Anti-oxidant Hepatotoxicity | MIF; nAChR 7α |
16 | Sanguilutine | Anti-proliferative | HSD1; MIF; PDE4D; PLA2s; FabZ |
17 | Sanguidimerine | Unreported | ATTP |
18 | Chelidimerine | Unreported | MDR HIV-1 Protease |
19 | Chelanthifoline | Anti-malarial | ALR; ERα; ERβ; MIF; PDK-1; CK2; PIM1; Pi3 Kγ; GR; nAChR 7α; TEM-1; ActR; MAO-B; HIV-1 RT; OSBP |
20 | Dehydrocicanthifoline | Unreported | HSD1; MR; PDE4B; PDE4D; PPO; MIF; TTR; JNK3; CRBP-2; MAPK p38; AR; PIM1; ZipA-FtsZ; HS5B Pol; HIV-1 RT |
21 | Berberine | Anti-fungal Anti-malarial Anti-cancer Cytotoxic Anti-inflammatory Anti-Alzheimer’s Anti-fertility Anti-diabetes | MIF; FabZ; Scy D; AchE |
22 | Dehydrochelanthifoline | Anti-virus | ERα; ERβ; MIF; GSK-3β; TTR; CDK2; PLA2s; MAO-B |
23 | Coptisine | Cytotoxic Anti-diabetes CYP2D6 inhibition Anti-oxidative Anti-spasmodic | MIF |
24 | α-Allocryptopine | Anti-funga Anti-arrhythmic | HSD1; MIF; HS5B Pol; Scy D; BACE1 |
25 | β-Allocryptopine | Anti-parasitic Anti-hepatic fibrosis | HSD1; MIF; HS5B POl; Scy D; BACE1; CRALBP; PPO; TTR; nAChR 7α |
26 | Protopine | Anti-malarial Anti-parasitic Anti-fertility Anti-spasmodic | NQO1; PfENR; TtgR |