Fig. 4
From: Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro
Effects on the MCR of STS under inhibition of CYP3A4 by KET (1 µM). STS (10 or 50 μM) was incubated with CYP3A4 and cofactors in the absence (control) or presence of KET. Each point represents the mean ± SD of triple incubations. The MCR of STS was significantly decreased compared with the control value for CYP3A4, for both concentrations of STS