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Table 2 Cytotoxicity of plant extracts in HepG2 and vero cells (mean ± SD) (n = 5)

From: Induction of apoptosis in human hepatocellular carcinoma cells by extracts of Lannea coromandelica (Houtt.) Merr. and Diospyros castanea (Craib) Fletcher

Plant Part used % yield IC50 ± SD (μg/mL) SI
HepG2 Vero
L. coromandelica (LC) Twig 6.01 307.12 ± 15.97a 489.37 ± 37.43 1.6a
C. tomentosa (CT) Twig 6.88 316.70 ± 34.82 294.59 ± 76.25 0.9
E. succirubrum (ES) Twig 8.94 207.89 ± 40.89 94.18 ± 29.10 0.4
D. castanea (DC) Leaves 7.23 147.12 ± 10.34a 237.11 ± 43.03 1.6a
D. castanea (DC) Twig 8.74 112.35 ± 18.26b >500 >4.5b, c
B. anceps (BA) Twig 5.96 212.74 ± 27.01a >500 2.3a
Melphalan    39.79 ± 7.62 178.98 ± 15.25 4.5
  1. aModerate cytotoxicity with lower selectivity index (SI < 3.0)
  2. bHigh cytotoxicity with higher selectivity index (SI > 3.0) to HepG2 cell lines
  3. cNon-significant difference vs. melphalan (P > 0.05)