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Table 4 Terminal deoxynucleotidyl-transferase dUTP nick end-labeling (TUNEL)

From: Chi-Ju-Di-Huang-Wan protects rats against retinal ischemia by downregulating matrix metalloproteinase-9 and inhibiting p38 mitogen-activated protein kinase

Group 1 2 3 4
Apoptotic cell No. on day 1 0 1.40 ± 0.55** 0.80 ± 0.45 0.40 ± 0.55
Apoptotic cell No. on day 7 0 1.40 ± 0.55** 0.80 ± 0.84 0.60 ± 0.55
  1. No TUNEL-positive apoptotic cell was observed 1 or 7 days after the sham procedure (Sham; Group 1). After retinal ischemia plus 1 or 7 days of reperfusion and pretreatment with vehicle (I/R + vehicle; Group 2), the number of apoptotic cells was significantly (** P < 0.01) increased in the retinal ganglion cell layer. In contrast, this significant increase was dose-dependently (with a less effect at 2.8 g/kg/day, I/R + CJDHW2.8; Group 3) and significantly ( P < 0.05; at 4.2 g/kg/day, I/R + CJDHW4.2; Group 4) inhibited by pretreatment with CJDHW. The results are the mean ± SD (n = 5)