Table 3 Four categories of disease targets of the selected compounds from profiling
Target | No. of hit compound | Drugsa |
|---|---|---|
Osteoporosis | Â | |
ABL1 | 2 | Nilotinib, saracatinib, regorafenib |
ER-α | 4 | 17-α-ethinylestradiol, fulvestrant, β-estradiol |
CSF1R | 2 | Nilotinib, sunitinib, pazopanib |
MMP3 | 1 | Marimastat |
C-src | 2 | Dasatinib, AZM-475271, saracatinib, |
MMP9 | 1 | Â |
MMP13 | 3 | Marimastat |
CDK9 | 1 | BMS-387032, alvocidib |
Prostate cancer | ||
Hsp90-α | 15 | Alvespimycin, retaspimycin, luminespib |
MMP3 | 1 | Marimastat |
MET | 1 | Crizotinib, tivantinib, cabozantinib |
AR | 3 | Testosterone enanthate, enzalutamide, 1-testosterone |
MMP9 | 1 | Â |
RXR-α | 4 | Etretinate, tretinoin, bexarotene |
MMP12 | 4 | Marimastat |
MMP13 | 3 | Marimastat |
MAP2K1 | 3 | Selumetinib, trametinib, dabrafenib |
Kidney diseases | ||
MMP9 | 1 | Â |
CA2 | 11 | Ethoxyzolamide, dichlorphenamide, brinzolamide |
P450scc | 22 | Â |
MET | 1 | Crizotinib, tivantinib, cabozantinib |
MIF | 1 | Â |
sEH | 2 | Â |
PPAR-γ | 20 | Icosapent, amlodipine/telmisartan, aleglitazar, |
MMP12 | 4 | Marimastat |
KIF11 | 23 | Â |
MAPK14 | 19 | Talmapimod, RO-3201195 |
CA9 | 1 | Girentuximab, methazolamide, hydrochlorothiazide |
Cardiovascular diseases | ||
JAK2 | 19 | Tofacitinib, ruxolitinib |
F2 | 8 | Enoxaparin, desirudin, dabigatran etexilate |
F10 | 15 | Dalteparin, heparin, enoxaparin |
REN | 1 | Aliskiren, aliskiren/valsartan, aliskiren/amlodipine |
CA1 | 1 | Ethoxyzolamide, dichlorphenamide, brinzolamide |
ER-α | 4 | 17-α-ethinylestradiol, fulvestrant, β-estradiol |
MMP3 | 1 | Marimastat |
LTA4H | 3 | Â |
THR-β | 1 | Amiodarone, levothyroxine, dextrothyroxine, |
FGFR1 | 16 | Pazopanib, nintedanib, regorafenib |
PLA2G2A | 7 | Varespladib methyl, varespladib, indomethacin |
FLT1 | 3 | Sunitinib, pazopanib, axitinib |
FGFR2 | 2 | Nintedanib, regorafenib, dexamethasone/thalidomide |
CDK2 | 26 | BMS-387032, alvocidib |
EPHX2 | 2 | Â |
KDR | 8 | Sunitinib, cediranib, pazopanib |
PPAR-γ | 20 | Icosapent, amlodipine/telmisartan, aleglitazar, |
MMP12 | 4 | Marimastat |
MMP13 | 3 | Marimastat |
PIK3CG | 12 | Dactolisib, buparlisib, |
GSK3-β | 2 | Enzastaurin |
CDK9 | 1 | BMS-387032, alvocidib |
MAPK10 | 7 | Â |
NR1H2 | 4 | Â |
DHODH | 7 | Teriflunomide, leflunomide |
PPAR-δ | 8 | Treprostinil, icosapent, bezafibrate |
PPAR-α | 2 | Choline fenofibrate, aleglitazar, gemfibrozil |
MAPK14 | 19 | Talmapimod, RO-3201195 |
NR1H4 | 1 | Â |