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Table 3 Absorption parameters of triptolide of various formulae in perfusate solution within duodenum, jejunum, ileum and colon (\( {\bar{\text{x}}} \pm {\text{s}} \), n = 6)

From: Different modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine

Parameters Con. (μg/mL) Duodenum Jejunum Ileum Colon
Peff × 10−3 Triptolide 5.2 ± 1.72 4.98 ± 1.67 6.46 ± 2.0 6.35 ± 1.28
TW 8.5 ± 3.61 5.54 ± 1.54 7.87 ± 1.68 8.35 ± 1.17#
TW-PN 4.2 ± 1.23* 4.3 ± 0.98 5.9 ± 0.86* 5.36 ± 0.75**
TW-CS 6.8 ± 2.12 5.4 ± 1.77 6.68 ± 0.9 6.95 ± 0.72*
QLTB 2.8 ± 0.54** 4.03 ± 1.55 5.28 ± 0.81** 5.73 ± 0.26**
10 cm%ABS Triptolide 42.7 ± 8.51 41.3 ± 9.1 42.8 ± 6.64 41.1 ± 3.33
TW 45.6 ± 5.83 42.5 ± 4.3 43.4 ± 2.33 47.8 ± 2.76##
TW-PN 37.38 ± 6.47* 28.9 ± 3.5** 37.9 ± 1.67** 29.9 ± 5.32**
TW-CS 38.38 ± 4.21* 30.5 ± 7.3** 42.5 ± 2.12 27.9 ± 5.09**
QLTB 29.9 ± 4.33** 23.1 ± 2.1** 28.4 ± 3.17** 21.5 ± 3.19**
Ka × 10−2 Triptolide 1.79 ± 0.33 1.64 ± 0.39 2.93 ± 0.29 1.81 ± 0.11
TW 1.83 ± 0.82 2.63 ± 0.47## 2.31 ± 0.30## 1.95 ± 0.20
TW-PN 0.93 ± 0.29* 1.34 ± 0.11** 1.76 ± 0.45* 1.71 ± 0.36
TW-CS 1.19 ± 0.56 1.11 ± 0.25** 2.18 ± 0.35 1.55 ± 0.26*
QLTB 1.27 ± 0.395 0.88 ± 0.25** 1.52 ± 0.21** 1.15 ± 0.22**
  1. #p < 0.05, ## p < 0.01, compared with triptolide; * p < 0.05, ** p < 0.01, compared with TW