Parameters | Con. (μg/mL) | Duodenum | Jejunum | Ileum | Colon |
---|---|---|---|---|---|
Peff × 10−3 | Triptolide | 5.2 ± 1.72 | 4.98 ± 1.67 | 6.46 ± 2.0 | 6.35 ± 1.28 |
TW | 8.5 ± 3.61 | 5.54 ± 1.54 | 7.87 ± 1.68 | 8.35 ± 1.17# | |
TW-PN | 4.2 ± 1.23* | 4.3 ± 0.98 | 5.9 ± 0.86* | 5.36 ± 0.75** | |
TW-CS | 6.8 ± 2.12 | 5.4 ± 1.77 | 6.68 ± 0.9 | 6.95 ± 0.72* | |
QLTB | 2.8 ± 0.54** | 4.03 ± 1.55 | 5.28 ± 0.81** | 5.73 ± 0.26** | |
10 cm%ABS | Triptolide | 42.7 ± 8.51 | 41.3 ± 9.1 | 42.8 ± 6.64 | 41.1 ± 3.33 |
TW | 45.6 ± 5.83 | 42.5 ± 4.3 | 43.4 ± 2.33 | 47.8 ± 2.76## | |
TW-PN | 37.38 ± 6.47* | 28.9 ± 3.5** | 37.9 ± 1.67** | 29.9 ± 5.32** | |
TW-CS | 38.38 ± 4.21* | 30.5 ± 7.3** | 42.5 ± 2.12 | 27.9 ± 5.09** | |
QLTB | 29.9 ± 4.33** | 23.1 ± 2.1** | 28.4 ± 3.17** | 21.5 ± 3.19** | |
Ka × 10−2 | Triptolide | 1.79 ± 0.33 | 1.64 ± 0.39 | 2.93 ± 0.29 | 1.81 ± 0.11 |
TW | 1.83 ± 0.82 | 2.63 ± 0.47## | 2.31 ± 0.30## | 1.95 ± 0.20 | |
TW-PN | 0.93 ± 0.29* | 1.34 ± 0.11** | 1.76 ± 0.45* | 1.71 ± 0.36 | |
TW-CS | 1.19 ± 0.56 | 1.11 ± 0.25** | 2.18 ± 0.35 | 1.55 ± 0.26* | |
QLTB | 1.27 ± 0.395 | 0.88 ± 0.25** | 1.52 ± 0.21** | 1.15 ± 0.22** |