Skip to main content

Table 3 Absorption parameters of triptolide of various formulae in perfusate solution within duodenum, jejunum, ileum and colon (\( {\bar{\text{x}}} \pm {\text{s}} \), n = 6)

From: Different modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine

Parameters

Con. (μg/mL)

Duodenum

Jejunum

Ileum

Colon

Peff × 10−3

Triptolide

5.2 ± 1.72

4.98 ± 1.67

6.46 ± 2.0

6.35 ± 1.28

TW

8.5 ± 3.61

5.54 ± 1.54

7.87 ± 1.68

8.35 ± 1.17#

TW-PN

4.2 ± 1.23*

4.3 ± 0.98

5.9 ± 0.86*

5.36 ± 0.75**

TW-CS

6.8 ± 2.12

5.4 ± 1.77

6.68 ± 0.9

6.95 ± 0.72*

QLTB

2.8 ± 0.54**

4.03 ± 1.55

5.28 ± 0.81**

5.73 ± 0.26**

10 cm%ABS

Triptolide

42.7 ± 8.51

41.3 ± 9.1

42.8 ± 6.64

41.1 ± 3.33

TW

45.6 ± 5.83

42.5 ± 4.3

43.4 ± 2.33

47.8 ± 2.76##

TW-PN

37.38 ± 6.47*

28.9 ± 3.5**

37.9 ± 1.67**

29.9 ± 5.32**

TW-CS

38.38 ± 4.21*

30.5 ± 7.3**

42.5 ± 2.12

27.9 ± 5.09**

QLTB

29.9 ± 4.33**

23.1 ± 2.1**

28.4 ± 3.17**

21.5 ± 3.19**

Ka × 10−2

Triptolide

1.79 ± 0.33

1.64 ± 0.39

2.93 ± 0.29

1.81 ± 0.11

TW

1.83 ± 0.82

2.63 ± 0.47##

2.31 ± 0.30##

1.95 ± 0.20

TW-PN

0.93 ± 0.29*

1.34 ± 0.11**

1.76 ± 0.45*

1.71 ± 0.36

TW-CS

1.19 ± 0.56

1.11 ± 0.25**

2.18 ± 0.35

1.55 ± 0.26*

QLTB

1.27 ± 0.395

0.88 ± 0.25**

1.52 ± 0.21**

1.15 ± 0.22**

  1. #p < 0.05, ## p < 0.01, compared with triptolide; * p < 0.05, ** p < 0.01, compared with TW