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Table 9 Absorption parameters of tripterine of various formulae in perfusate solution within duodenum, jejunum, ileum and colon (\( {\bar{\text{x}}} \pm {\text{s}} \), n = 6)

From: Different modulation of Panax notoginseng on the absorption profiling of triptolide and tripterine from Tripterygium wilfordii in rat intestine

Parameters

Con. (μg/mL)

Duodenum

Jejunum

Ileum

Colon

Peff × 10−3

Tripterine

6.78 ± 3.68

8.72 ± 3.47

9.48 ± 2.91

10.3 ± 1.56

TW

7.11 ± 2.77

10.7 ± 4.51

11.6 ± 3.01

12.4 ± 3.63

TW-PN

10.3 ± 1.14*

13.3 ± 4.08

15.2 ± 2.63

9.98 ± 0.21

TW-CS

3.20 ± 0.49**

3.35 ± 0.78**

5.69 ± 2.12**

3.39 ± 1.15**

QLTB

11.7 ± 0.82**

11.1 ± 5.3

6.10 ± 3.63*

5.62 ± 3.11**

10 cm%ABS

Tripterine

4.76 ± 1.27

4.98 ± 2.46

5.62 ± 1.81

6.34 ± 1.63

TW

5.87 ± 1.23

6.27 ± 2.26

7.60 ± 1.17#

7.14 ± 1.63

TW-PN

6.49 ± 1.91

9.29 ± 0.54**

9.43 ± 0.56**

5.82 ± 1.42

TW-CS

2.91 ± 0.49**

3.74 ± 0.95*

4.23 ± 2.67*

3.97 ± 1.19**

QLTB

8.13 ± 0.81**

7.38 ± 1.07

4.84 ± 1.58**

5.65 ± 1.31

Ka × 10−2

Tripterine

1.52 ± 0.41

2.08 ± 0.33

2.62 ± 0.17

1.27 ± 0.19

TW

1.88 ± 0.38

2.21 ± 0.51

2.91 ± 0.35

1.34 ± 0.54

TW-PN

2.31 ± 0.83

3.27 ± 0.21**

3.21 ± 0.14

2.52 ± 0.13**

TW-CS

1.64 ± 0.30

1.22 ± 0.20**

1.39 ± 0.40**

1.54 ± 0.11

QLTB

2.14 ± 0.30

1.69 ± 0.45

1.86 ± 0.16**

1.66 ± 0.31

  1. #p < 0.05, compared with tripterine; * p < 0.05, ** p < 0.01, compared with TW